HCSGD entry for NDUFA4
1. General information
| Official gene symbol | NDUFA4 |
|---|---|
| Entrez ID | 4697 |
| Gene full name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa |
| Other gene symbols | CI-9k CI-MLRQ MLRQ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004129 | Cytochrome-c oxidase activity | IMP | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005747 | Mitochondrial respiratory chain complex I | IDA NAS | cellular_component |
| GO:0005751 | Mitochondrial respiratory chain complex IV | IDA | cellular_component |
| GO:0006120 | Mitochondrial electron transport, NADH to ubiquinone | NAS | biological_process |
| GO:0006810 | Transport | IMP | biological_process |
| GO:0006812 | Cation transport | IMP | biological_process |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | NAS | molecular_function |
| GO:0015672 | Monovalent inorganic cation transport | IMP | biological_process |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0034220 | Ion transmembrane transport | IMP | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055085 | Transmembrane transport | IMP | biological_process |
| GO:1902600 | Hydrogen ion transmembrane transport | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8236678508 | 0.2445856047 | 0.9999902473 | 0.9524413635 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0111187558 |
| GSE13712_SHEAR | Down | -0.1401273659 |
| GSE13712_STATIC | Down | -0.0717283569 |
| GSE19018 | Up | 0.0374829573 |
| GSE19899_A1 | Down | -0.0549222254 |
| GSE19899_A2 | Down | -0.2968612415 |
| PubMed_21979375_A1 | Down | -0.1435574570 |
| PubMed_21979375_A2 | Down | -0.1179150202 |
| GSE35957 | Up | 0.0277266202 |
| GSE36640 | Up | 0.2548949306 |
| GSE54402 | Up | 0.1556912704 |
| GSE9593 | Down | -0.0676649549 |
| GSE43922 | Down | -0.2003705181 |
| GSE24585 | Up | 0.0188238963 |
| GSE37065 | Down | -0.2240199366 |
| GSE28863_A1 | Up | 0.4876248966 |
| GSE28863_A2 | Down | -0.1999590824 |
| GSE28863_A3 | Down | -0.2614765219 |
| GSE28863_A4 | Up | 0.0470899673 |
| GSE48662 | Down | -0.0650989859 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | MIRT021524 | Reporter assay;Microarray | Functional MTI | 21351259 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025792 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031645 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-147b | MIMAT0004928 | MIRT037742 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045020 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
