HCSGD entry for NCAM1
1. General information
| Official gene symbol | NCAM1 |
|---|---|
| Entrez ID | 4684 |
| Gene full name | neural cell adhesion molecule 1 |
| Other gene symbols | CD56 MSK39 NCAM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001928 | Regulation of exocyst assembly | IEA | biological_process |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IDA IEA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0034109 | Homotypic cell-cell adhesion | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0050850 | Positive regulation of calcium-mediated signaling | IEA | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6949375214 | 0.6644687702 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0676435718 |
| GSE13712_SHEAR | Down | -0.0154684786 |
| GSE13712_STATIC | Down | -0.0081703197 |
| GSE19018 | Up | 0.0602930709 |
| GSE19899_A1 | Up | 0.1181748631 |
| GSE19899_A2 | Up | 0.0666951284 |
| PubMed_21979375_A1 | Up | 0.1202021357 |
| PubMed_21979375_A2 | Down | -0.0029509833 |
| GSE35957 | Down | -0.2474822760 |
| GSE36640 | Up | 0.0570006657 |
| GSE54402 | Up | 0.0549919429 |
| GSE9593 | Down | -0.0142995753 |
| GSE43922 | Up | 0.0144841640 |
| GSE24585 | Down | -0.1043516049 |
| GSE37065 | Down | -0.7794245147 |
| GSE28863_A1 | Down | -0.0528872623 |
| GSE28863_A2 | Up | 0.9925092252 |
| GSE28863_A3 | Up | 0.1344850529 |
| GSE28863_A4 | Down | -0.0504500201 |
| GSE48662 | Down | -0.0210699509 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003090 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003090 | Microarray | Functional MTI (Weak) | 17179747 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003090 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT003159 | immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 19826008 |
| hsa-miR-375 | MIMAT0000728 | MIRT019976 | qRT-PCR;Microarray | Functional MTI (Weak) | 20584986 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24185682 | CCR2 or CX3CR1-expressing cells were characterized by double immunofluorescence with CD3, CD4, CD8, CD56 or CD68 |
| 23841748 | Here, using quantitative RT-PCR and flow cytometry [fluorescence-activated cell sorting (FACS)] analysis, we show in VPA-treated primary cultures of human adult and fetal kidney significant reinduction of the renal stem/progenitor markers SIX2, OSR1, SALL1, NCAM, and PSA-NCAM |
| 20093230 | NCAM was frequently coexpressed in ductular cells showing senescence-associated markers |
| 17379755 | Blood lymphocytes isolated before, immediately after, and 1 h after exercise were assessed for cell surface expression of KLRG1, CD57, CD28, CD45RA, CD45RO, CD62L, and lymphocyte subset markers (CD3, CD4, CD8, CD56) by flow cytometry |
| 17195207 | RESULTS: Chronic stimulation of CD28(+) T cells in vitro yielded progenies that lacked CD28 but that gained CD56 |
| 17195207 | CD56 crosslinking on T cells sufficiently induced cytokine production, although CD56/TCR coligation induced higher production levels |
| 17195207 | CONCLUSION: Chronic activation of T cells induces counterregulation of CD28 and CD56 expression |
| 17195207 | The loss of CD28 is accompanied by the gain of CD56 that confers TCR-independent and TCR-dependent activation pathways |
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