HCSGD entry for ATF3
1. General information
| Official gene symbol | ATF3 |
|---|---|
| Entrez ID | 467 |
| Gene full name | activating transcription factor 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006094 | Gluconeogenesis | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0233375138 | 0.5556025873 | 0.3627449088 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3429243455 |
| GSE13712_SHEAR | Up | 1.3404391348 |
| GSE13712_STATIC | Up | 0.8481297742 |
| GSE19018 | Up | 0.1800902011 |
| GSE19899_A1 | Up | 0.2879317790 |
| GSE19899_A2 | Up | 0.1405342549 |
| PubMed_21979375_A1 | Up | 0.3974197252 |
| PubMed_21979375_A2 | Up | 0.5714231234 |
| GSE35957 | Down | -0.5606435568 |
| GSE36640 | Up | 0.7974139805 |
| GSE54402 | Down | -0.2060415196 |
| GSE9593 | Up | 1.2298539697 |
| GSE43922 | Down | -0.0631717056 |
| GSE24585 | Down | -0.3566565783 |
| GSE37065 | Up | 0.2393221286 |
| GSE28863_A1 | Down | -0.3559903191 |
| GSE28863_A2 | Up | 0.2586426244 |
| GSE28863_A3 | Down | -0.0754819186 |
| GSE28863_A4 | Up | 0.1991796376 |
| GSE48662 | Down | -0.0634943030 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029081 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043494 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050819 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25531190 | Activating transcription factor 3 (ATF3) plays a pleiotropic role in biological processes through genotoxic stress |
| 25531190 | In this study, we examined the effects of acrylamide (ACR), a genotoxic carcinogen, on cellular senescence and the molecular mechanisms of ATF3 function in macrophages |
| 25531190 | In addition, ACR treatment for 1, 3, or 5 days showed a concentration-dependent increase in ATF3 expression and G0/G1 phase arrest |
| 25531190 | To better understand the role of ATF3 in controlling the senescence response to ACR, SA-beta-gal activity was examined using ATF3 knockdown and overexpression |
| 25531190 | ACR-mediated senescence was significantly decreased by knockdown of ATF3, whereas it was increased with ATF3 overexpression |
| 25531190 | We found that ATF3 regulated p53 and p21 levels |
| 25531190 | ATF3 also played an important role in regulating intracellular reactive oxygen species (ROS) production in response to ACR treatment |
| 21406393 | The underlying mechanism involves interruption of a double negative regulatory axis, whereby calcineurin and nuclear factors of activated T-cell signaling inhibits expression of ATF3, a negative regulator of p53 |
| 20485437 | Opposing roles for calcineurin and ATF3 in squamous skin cancer |
| 20485437 | ATF3, a member of the 'enlarged' AP-1 family, is selectively induced by calcineurin/NFAT inhibition, both under experimental conditions and in clinically occurring tumours, and increased ATF3 expression accounts for suppression of p53-dependent senescence and enhanced tumorigenic potential |
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