HCSGD entry for MYOD1

1. General information

Official gene symbolMYOD1
Entrez ID4654
Gene full namemyogenic differentiation 1
Other gene symbolsMYF3 MYOD PUM bHLHc1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000381Regulation of alternative mRNA splicing, via spliceosomeIEAbiological_process
GO:0000790Nuclear chromatinISScellular_component
GO:0001047Core promoter bindingISSmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexISScellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006468Protein phosphorylationTASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0007518Myoblast fate determinationIEAbiological_process
GO:0007519Skeletal muscle tissue developmentTASbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0009267Cellular response to starvationIEAbiological_process
GO:0014904Myotube cell developmentIDAbiological_process
GO:0014908Myotube differentiation involved in skeletal muscle regenerationIEAbiological_process
GO:0030016MyofibrilIEAcellular_component
GO:0031490Chromatin DNA bindingISSmolecular_function
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0042692Muscle cell differentiationTASbiological_process
GO:0042693Muscle cell fate commitmentISSbiological_process
GO:0043415Positive regulation of skeletal muscle tissue regenerationIEAbiological_process
GO:0043484Regulation of RNA splicingIDAbiological_process
GO:0043503Skeletal muscle fiber adaptationIEAbiological_process
GO:0043966Histone H3 acetylationISSbiological_process
GO:0043967Histone H4 acetylationISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046982Protein heterodimerization activityISSmolecular_function
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
GO:0051149Positive regulation of muscle cell differentiationIDA TASbiological_process
GO:0070888E-box bindingISSmolecular_function
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
GO:0071392Cellular response to estradiol stimulusISSbiological_process
GO:0071453Cellular response to oxygen levelsIEAbiological_process
GO:1901741Positive regulation of myoblast fusionIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47270932340.80910942210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0646914702
GSE13712_SHEARDown-0.1485219505
GSE13712_STATICUp0.0284162146
GSE19018Up0.1676848178
GSE19899_A1Down-0.0527684931
GSE19899_A2Up0.0530466547
PubMed_21979375_A1Up0.2347891968
PubMed_21979375_A2Down-0.0162038229
GSE35957Up0.3007361519
GSE36640Up0.1153254343
GSE54402Down-0.0283512777
GSE9593Down-0.0284131509
GSE43922Up0.0244013520
GSE24585Up0.2506906654
GSE37065Up0.0615024873
GSE28863_A1Down-0.1362396405
GSE28863_A2Down-0.1087493874
GSE28863_A3Up0.4510558807
GSE28863_A4Down-0.0187419883
GSE48662Down-0.0925763876

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019143MicroarrayFunctional MTI (Weak)18185580
hsa-miR-324-5pMIMAT0000761MIRT043226CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26885755Myogenesis was defected in muscle cell culture from diseased muscles but was restored by elevating MyoD levels
11937715The expression levels of MyoD, myogenin, MHC and p21 were also reduced in these clones
11374435Myf-5 and MyoD are the two muscle regulatory factors expressed from the myoblast stage to maintain the identity and to promote the subsequent differentiation of muscle precursor cells
11374435That a null mutation in either gene reduces the proliferative potential of cultured myoblasts raises the possibility that Myf-5 and MyoD serve proliferation of muscle precursor cells
Entries Per Page
Displaying Page of