HCSGD entry for MYL2
1. General information
| Official gene symbol | MYL2 |
|---|---|
| Entrez ID | 4633 |
| Gene full name | myosin, light chain 2, regulatory, cardiac, slow |
| Other gene symbols | CMH10 MLC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003785 | Actin monomer binding | IDA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IDA | cellular_component |
| GO:0006942 | Regulation of striated muscle contraction | TAS | biological_process |
| GO:0008307 | Structural constituent of muscle | NAS | molecular_function |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0016459 | Myosin complex | TAS | cellular_component |
| GO:0030016 | Myofibril | NAS | cellular_component |
| GO:0030017 | Sarcomere | TAS | cellular_component |
| GO:0030049 | Muscle filament sliding | TAS | biological_process |
| GO:0030308 | Negative regulation of cell growth | IMP | biological_process |
| GO:0031672 | A band | IEA | cellular_component |
| GO:0032036 | Myosin heavy chain binding | NAS | molecular_function |
| GO:0042694 | Muscle cell fate specification | IEA | biological_process |
| GO:0048747 | Muscle fiber development | IEA | biological_process |
| GO:0055003 | Cardiac myofibril assembly | ISS | biological_process |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IMP | biological_process |
| GO:0060047 | Heart contraction | ISS | biological_process |
| GO:0060048 | Cardiac muscle contraction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5427278295 | 0.6888025911 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2369329681 |
| GSE13712_SHEAR | Down | -0.1092067572 |
| GSE13712_STATIC | Down | -0.1226331589 |
| GSE19018 | Up | 0.2701833032 |
| GSE19899_A1 | Up | 0.1049105401 |
| GSE19899_A2 | Up | 0.1978065562 |
| PubMed_21979375_A1 | Up | 0.2975529298 |
| PubMed_21979375_A2 | Up | 0.0462983891 |
| GSE35957 | Up | 0.2409768084 |
| GSE36640 | Up | 0.0168895646 |
| GSE54402 | Down | -0.0233559916 |
| GSE9593 | Up | 0.0838202930 |
| GSE43922 | Down | -0.0374772232 |
| GSE24585 | Up | 0.0076149479 |
| GSE37065 | Down | -0.0841818756 |
| GSE28863_A1 | Down | -0.0937230948 |
| GSE28863_A2 | Down | -0.0733436656 |
| GSE28863_A3 | Up | 0.1537341179 |
| GSE28863_A4 | Up | 0.0414046579 |
| GSE48662 | Down | -0.6702513370 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048671 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
