HCSGD entry for ZFHX3
1. General information
| Official gene symbol | ZFHX3 |
|---|---|
| Entrez ID | 463 |
| Gene full name | zinc finger homeobox 3 |
| Other gene symbols | ATBF1 ATBT ZNF927 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IGI | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007517 | Muscle organ development | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045662 | Negative regulation of myoblast differentiation | IDA | biological_process |
| GO:0045663 | Positive regulation of myoblast differentiation | IDA | biological_process |
| GO:0045664 | Regulation of neuron differentiation | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6119241214 | 0.4421557502 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1997384015 |
| GSE13712_SHEAR | Up | 0.1400385301 |
| GSE13712_STATIC | Up | 0.1106765215 |
| GSE19018 | Down | -0.0897172410 |
| GSE19899_A1 | Down | -0.0017692704 |
| GSE19899_A2 | Down | -0.0163188917 |
| PubMed_21979375_A1 | Down | -0.6020128694 |
| PubMed_21979375_A2 | Up | 0.0356172506 |
| GSE35957 | Down | -0.1253559147 |
| GSE36640 | Up | 0.1775153721 |
| GSE54402 | Down | -0.1781613980 |
| GSE9593 | Down | -0.2690888683 |
| GSE43922 | Up | 0.0467425781 |
| GSE24585 | Down | -0.0468867851 |
| GSE37065 | Down | -0.1325041665 |
| GSE28863_A1 | Up | 0.4054819474 |
| GSE28863_A2 | Up | 0.6976082677 |
| GSE28863_A3 | Down | -0.0608812683 |
| GSE28863_A4 | Down | -0.0188774784 |
| GSE48662 | Up | 0.0825672460 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019620 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027177 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027754 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031857 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-532-5p | MIMAT0002888 | MIRT040982 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047244 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
