HCSGD entry for MYH9

1. General information

Official gene symbolMYH9
Entrez ID4627
Gene full namemyosin, heavy chain 9, non-muscle
Other gene symbolsBDPLT6 DFNA17 EPSTS FTNS MHA NMHC-II-A NMMHC-IIA NMMHCA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000146Microfilament motor activityIDAmolecular_function
GO:0000212Meiotic spindle organizationIEAbiological_process
GO:0000904Cell morphogenesis involved in differentiationIEAbiological_process
GO:0000910CytokinesisIMPbiological_process
GO:0001525AngiogenesisIDAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001725Stress fiberIDAcellular_component
GO:0001726RuffleIDAcellular_component
GO:0001768Establishment of T cell polarityIEAbiological_process
GO:0001772Immunological synapseIDA IEAcellular_component
GO:0001931UropodIDA IEAcellular_component
GO:0003774Motor activityIEA NASmolecular_function
GO:0003779Actin bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005826Actomyosin contractile ringIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005913Cell-cell adherens junctionIEAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0006928Cellular component movementIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayNASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007520Myoblast fusionIEAbiological_process
GO:0008180COP9 signalosomeIDAcellular_component
GO:0008305Integrin complexIDAcellular_component
GO:0008360Regulation of cell shapeIMPbiological_process
GO:0015031Protein transportIMPbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0016459Myosin complexIEAcellular_component
GO:0016460Myosin II complexIEAcellular_component
GO:0016887ATPase activityIDAmolecular_function
GO:0030048Actin filament-based movementIDAbiological_process
GO:0030220Platelet formationIMPbiological_process
GO:0030224Monocyte differentiationIEPbiological_process
GO:0030863Cortical cytoskeletonIEAcellular_component
GO:0030898Actin-dependent ATPase activityIDAmolecular_function
GO:0031252Cell leading edgeIDAcellular_component
GO:0031532Actin cytoskeleton reorganizationIMPbiological_process
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0032154Cleavage furrowIDAcellular_component
GO:0032796Uropod organizationIEAbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043495Protein anchorIMPmolecular_function
GO:0043531ADP bindingIDAmolecular_function
GO:0043534Blood vessel endothelial cell migrationIMPbiological_process
GO:0050900Leukocyte migrationNASbiological_process
GO:0051015Actin filament bindingIDA IEA NASmolecular_function
GO:0051295Establishment of meiotic spindle localizationIEAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64347650550.02223005960.99999024730.2864271659

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.6013373435
GSE13712_SHEARDown-0.1306829439
GSE13712_STATICDown-0.2132262616
GSE19018Up0.6039049990
GSE19899_A1Down-1.0055834303
GSE19899_A2Down-0.4480227786
PubMed_21979375_A1Down-0.7386290195
PubMed_21979375_A2Up0.0678388022
GSE35957Down-0.4007328579
GSE36640Down-0.5704577191
GSE54402Down-0.0540421774
GSE9593Up0.0029210823
GSE43922Down-0.4708264187
GSE24585Down-0.1049308661
GSE37065Down-0.3857233184
GSE28863_A1Up0.3691932254
GSE28863_A2Up0.4560034712
GSE28863_A3Up0.3149589218
GSE28863_A4Up0.1312116971
GSE48662Down-0.1383544074

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002579MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002579Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-9-5pMIMAT0000441MIRT021471MicroarrayFunctional MTI (Weak)17612493
hsa-miR-1296-5pMIMAT0005794MIRT036109CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT037181CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041494CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042190CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042922CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043426CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045466CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049384CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26152646Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people
26152646This does not mean that there is no physiological ageing process at all; in addition to those already elucidated, its mechanisms include cell senescence, podocyte dysfunction, a vitamin D deficiency, and homozygotic forms of the MYH9 gene
2615264673 m(2), plasma 25(OH)D3 levels and the MYH9 gene in a population of elderly and very elderly persons
26152646Here we observed a lower Hb level and an elevated Alb/Cr ratio in subjects heterozygotic for the MYH9 gene
26152646This could be interpreted in the sense that the gene could exert some protective effect on renal function, whereas the heterozygotic form (allele A) of the MYH9 gene could be considered a very early marker, a new risk factor for the appearance of CKD, or a sign of renal frailty in elderly people
24862015The central idea described here is the concept called the membrane hypothesis of aging (MHA)
24862015This chapter covers also the available anti-aging interventions on the cell membrane by means of the centrophenoxine treatment based on the MHA
23974104Drug affinity responsive target stability (DARTS) analysis identified IQ motif-containing factors IQGAP1 and MYH9 as direct binding targets of disulfiram
15374458This review summarizes the main points of an interdisciplinary, theoretically established approach to the problem of cell senescence, called membrane hypothesis of aging (MHA)
15374458It is emphasized that MHA is not an alternative to the other aging hypotheses but represents a synthesis of most of them
15374458It is pointed out that the new drug design based on the MHA resulted in a useful new molecule which is able to improve the key cell parameters deteriorated by advancing age
2653255According to the membrane hypothesis of aging (MHA), cellular senescence is attributable to a life-long, cross-linking action of oxygen-free radicals in the cell plasma membrane, resulting in a continuous decrease of the passive ion permeabilities
2653255MHA suggested that an age-dependent increase in the physical density of the intracellular mass can underly the well-known age-dependent decreases of the macromolecular synthetic processes, the enzymic turnover rates, etc
2653255MHA was partly based on a molecular enzyme kinetic model (MEKM) suggesting that environmental factors can substantially influence the enzyme catalysis and regulation through collisional coupling
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