HCSGD entry for MYH7
1. General information
| Official gene symbol | MYH7 |
|---|---|
| Entrez ID | 4625 |
| Gene full name | myosin, heavy chain 7, cardiac muscle, beta |
| Other gene symbols | CMD1S CMH1 MPD1 MYHCB SPMD SPMM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000146 | Microfilament motor activity | NAS | molecular_function |
| GO:0001725 | Stress fiber | IEA | cellular_component |
| GO:0002027 | Regulation of heart rate | IDA | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005859 | Muscle myosin complex | TAS | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006936 | Muscle contraction | IDA TAS | biological_process |
| GO:0007512 | Adult heart development | IMP | biological_process |
| GO:0008307 | Structural constituent of muscle | IDA | molecular_function |
| GO:0016459 | Myosin complex | TAS | cellular_component |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0030017 | Sarcomere | TAS | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0030049 | Muscle filament sliding | IMP | biological_process |
| GO:0030898 | Actin-dependent ATPase activity | IMP | molecular_function |
| GO:0032982 | Myosin filament | IDA | cellular_component |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8423077657 | 0.6468542913 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0663513810 |
| GSE13712_SHEAR | Down | -0.0099684150 |
| GSE13712_STATIC | Down | -0.0091830721 |
| GSE19018 | Down | -0.0562505843 |
| GSE19899_A1 | Down | -0.1434894595 |
| GSE19899_A2 | Up | 0.0513860389 |
| PubMed_21979375_A1 | Up | 0.5387313847 |
| PubMed_21979375_A2 | Up | 0.0481688654 |
| GSE35957 | Up | 0.0459517236 |
| GSE36640 | Down | -0.1984675807 |
| GSE54402 | Up | 0.0203420097 |
| GSE9593 | Up | 0.1690362119 |
| GSE43922 | Up | 0.0244105471 |
| GSE24585 | Down | -0.0649991554 |
| GSE37065 | Up | 0.0040309735 |
| GSE28863_A1 | Down | -0.0957894590 |
| GSE28863_A2 | Down | -0.1446192813 |
| GSE28863_A3 | Up | 0.2085512852 |
| GSE28863_A4 | Up | 0.0368760484 |
| GSE48662 | Down | -0.1569413390 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID | DB08378 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26152646 | Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people |
| 24028184 | RESULTS: Co-expression of alpha-smooth muscle actin and smooth muscle myosin heavy chain confirmed all cell populations as SMC |
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