HCSGD entry for MYH6

1. General information

Official gene symbolMYH6
Entrez ID4624
Gene full namemyosin, heavy chain 6, cardiac muscle, alpha
Other gene symbolsASD3 CMD1EE CMH14 MYHC MYHCA SSS3 alpha-MHC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000146Microfilament motor activityISSmolecular_function
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001725Stress fiberIEAcellular_component
GO:0002026Regulation of the force of heart contractionISSbiological_process
GO:0002027Regulation of heart rateIDAbiological_process
GO:0003779Actin bindingIEAmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005859Muscle myosin complexTAScellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006200ATP catabolic processIDA IMPbiological_process
GO:0006936Muscle contractionIDAbiological_process
GO:0006941Striated muscle contractionISSbiological_process
GO:0007512Adult heart developmentIMPbiological_process
GO:0007522Visceral muscle developmentISSbiological_process
GO:0008016Regulation of heart contractionISSbiological_process
GO:0008152Metabolic processIDA IMP ISSbiological_process
GO:0008217Regulation of blood pressureISSbiological_process
GO:0008307Structural constituent of muscleIDAmolecular_function
GO:0016459Myosin complexTAScellular_component
GO:0016887ATPase activityIDAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030016MyofibrilISScellular_component
GO:0030017SarcomereTAScellular_component
GO:0030018Z discIEAcellular_component
GO:0030049Muscle filament slidingIMP TASbiological_process
GO:0030239Myofibril assemblyISSbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0030898Actin-dependent ATPase activityIMPmolecular_function
GO:0032982Myosin filamentIEAcellular_component
GO:0043462Regulation of ATPase activityISSbiological_process
GO:0045214Sarcomere organizationISSbiological_process
GO:0048739Cardiac muscle fiber developmentISSbiological_process
GO:0055009Atrial cardiac muscle tissue morphogenesisIMPbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060420Regulation of heart growthIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92912872990.38817560500.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0247831174
GSE13712_SHEARUp0.1355330412
GSE13712_STATICDown-0.0291897585
GSE19018Down-0.2364275375
GSE19899_A1Down-0.0161467975
GSE19899_A2Down-0.0293956086
PubMed_21979375_A1Down-0.0412598231
PubMed_21979375_A2Down-0.1564715568
GSE35957Up0.0265176679
GSE36640Down-0.0646352285
GSE54402Up0.1121767566
GSE9593Down-0.2327010515
GSE43922Down-0.0115655307
GSE24585Down-0.1733761989
GSE37065Up0.0365218647
GSE28863_A1Down-0.0299051836
GSE28863_A2Down-0.1163079351
GSE28863_A3Up0.1001916696
GSE28863_A4Down-0.0269718255
GSE48662Down-0.1197071288

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23933320METHODS: We generated transgenic mice with cardiac-specific overexpression of SMP30 gene using alpha-myosin heavy chain promoter
Entries Per Page
Displaying Page of