HCSGD entry for GADD45B
1. General information
| Official gene symbol | GADD45B |
|---|---|
| Entrez ID | 4616 |
| Gene full name | growth arrest and DNA-damage-inducible, beta |
| Other gene symbols | GADD45BETA MYD118 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000185 | Activation of MAPKKK activity | IDA | biological_process |
| GO:0000186 | Activation of MAPKK activity | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IDA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
| GO:1900745 | Positive regulation of p38MAPK cascade | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2745492003 | 0.0109037954 | 0.9706392881 | 0.2064739568 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.4373994481 |
| GSE13712_SHEAR | Up | 0.9302918223 |
| GSE13712_STATIC | Up | 0.6320931750 |
| GSE19018 | Down | -0.0855213986 |
| GSE19899_A1 | Down | -0.2873207513 |
| GSE19899_A2 | Down | -1.2349144334 |
| PubMed_21979375_A1 | Down | -0.6136775212 |
| PubMed_21979375_A2 | Down | -1.4711304621 |
| GSE35957 | Up | 0.3698150853 |
| GSE36640 | Up | 0.5812759596 |
| GSE54402 | Down | -1.0245006496 |
| GSE9593 | Down | -0.2006299659 |
| GSE43922 | Down | -0.2368170168 |
| GSE24585 | Up | 0.9807671563 |
| GSE37065 | Down | -0.1877329089 |
| GSE28863_A1 | Down | -0.1500094669 |
| GSE28863_A2 | Down | -0.3711566649 |
| GSE28863_A3 | Up | 0.3046465474 |
| GSE28863_A4 | Up | 0.0576741105 |
| GSE48662 | Down | -0.1726902720 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26618897 | Downstream effects on DNA damage and senescence were investigated by western blot (gammaH2AX, GADD45beta and p21), flow cytometric analysis of cell cycle and light scattering properties, quantitative assessment of senescence associated beta galactosidase activity, and PAS staining |
| 26618897 | RESULTS: In vivo chondrocytes from obese OA patients showed higher levels of phosphorylated GSK3beta, oxidative damage and expression of GADD45beta and p21, in comparison with chondrocytes of nonobese OA patients |
| 26618897 | Collectively, western blot data supported the occurrence of a DNA damage response leading to cellular senescence with increase in gammaH2AX, GADD45beta and p21 |
| 21353395 | Growth arrest and DNA damage-inducible protein 45beta (GADD45beta) is expressed in normal and early osteoarthritic articular cartilage |
| 21353395 | We recently reported that GADD45beta enhances CCAAT/enhancer binding protein beta (C/EBPbeta) activation in vitro |
| 21353395 | This study was undertaken in order to determine whether GADD45beta is expressed with C/EBPbeta in aging articular cartilage |
| 21353395 | We also investigated whether the synergistic expression of GADD45beta and C/EBPbeta may be involved in the mechanism of chondrocyte senescence |
| 21353395 | GADD45beta, C/EBPbeta, and p21 were analyzed by immunohistochemistry |
| 21353395 | GADD45beta exhibited increased expression in the aging articular cartilage of SAMP1 mice compared to that in control mice |
| 21353395 | The co-localization of GADD45beta and C/EBPbeta was confirmed by double immunostaining |
| 21353395 | The synergistic mechanisms of GADD45beta and C/EBPbeta on the gene regulation of p21, a molecule related to cellular senescence, were verified by a p21-luciferase reporter assay |
| 21353395 | These observations suggest that the synergism between GADD45beta and C/EBPbeta may play an important role in cellular senescence in the aging articular cartilage |
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