HCSGD entry for MX1

1. General information

Official gene symbolMX1
Entrez ID4599
Gene full namemyxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
Other gene symbolsIFI-78K IFI78 MX MxA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006952Defense responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0009615Response to virusIMPbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0034340Response to type I interferonTASbiological_process
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051607Defense response to virusIEAbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00108135330.24874443220.08811857590.9587351296

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7684152929
GSE13712_SHEARUp7.6706714404
GSE13712_STATICUp3.8956415477
GSE19018Down-0.0078894197
GSE19899_A1Up0.0383548173
GSE19899_A2Down-0.0933958689
PubMed_21979375_A1Down-0.4127598206
PubMed_21979375_A2Down-0.0682307804
GSE35957Down-4.5279945726
GSE36640Up0.7419224714
GSE54402Down-0.0929952678
GSE9593Up0.4373487881
GSE43922Down-0.2020684661
GSE24585Up0.6795196007
GSE37065Up2.1944714745
GSE28863_A1Down-0.2892382196
GSE28863_A2Up1.1191138855
GSE28863_A3Up0.3706220130
GSE28863_A4Up0.0246235205
GSE48662Up0.5232096554

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19802007Here, we show that genotoxic drugs capable of inducing premature senescence in normal and cancer cells, such as 5-bromo-2'-deoxyuridine (BrdU), distamycin A (DMA), aphidicolin and hydroxyurea, persistently activate Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling and expression of interferon-stimulated genes (ISGs), such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7, in several human cancer cell lines
16539728The chromosome 21 gene MX1 was strongly over-expressed (mean 16-fold) in senescent +21 fibroblasts, a result verified by northern and western blotting
16539728MX1 is an interferon target gene, and its mRNA was induced by interferons present in +21 fibroblast conditioned medium, suggesting an autocrine loop for its over-expression
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