HCSGD entry for MVK
1. General information
| Official gene symbol | MVK |
|---|---|
| Entrez ID | 4598 |
| Gene full name | mevalonate kinase |
| Other gene symbols | LRBP MK MVLK POROK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004496 | Mevalonate kinase activity | IDA IEA IMP TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IDA TAS | biological_process |
| GO:0008299 | Isoprenoid biosynthetic process | IDA IEA | biological_process |
| GO:0019287 | Isopentenyl diphosphate biosynthetic process, mevalonate pathway | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8349194597 | 0.5993066867 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0058109100 |
| GSE13712_SHEAR | Down | -0.0654450091 |
| GSE13712_STATIC | Down | -0.1234738586 |
| GSE19018 | Up | 0.0612332058 |
| GSE19899_A1 | Up | 0.0320066303 |
| GSE19899_A2 | Up | 0.3469938046 |
| PubMed_21979375_A1 | Down | -0.1160068993 |
| PubMed_21979375_A2 | Down | -0.0856859403 |
| GSE35957 | Down | -0.0302584076 |
| GSE36640 | Up | 0.1666528488 |
| GSE54402 | Down | -0.0187933324 |
| GSE9593 | Down | -0.0032143813 |
| GSE43922 | Up | 0.1588336152 |
| GSE24585 | Down | -0.2797789921 |
| GSE37065 | Down | -0.1049337652 |
| GSE28863_A1 | Down | -0.1662608708 |
| GSE28863_A2 | Up | 0.0641878456 |
| GSE28863_A3 | Up | 0.0552061618 |
| GSE28863_A4 | Up | 0.1045405710 |
| GSE48662 | Down | -0.2306103504 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| FARNESYL THIOPYROPHOSPHATE | DB04695 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022207 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11748027 | We modified the two-stage Moolgavkar-Venzon-Knudson (MVK) model for use with Syrian hamster embryo (SHE) cell neoplastic progression |
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