HCSGD entry for MUTYH
1. General information
| Official gene symbol | MUTYH |
|---|---|
| Entrez ID | 4595 |
| Gene full name | mutY homolog (E. coli) |
| Other gene symbols | CYP2C MYH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | IEA TAS | biological_process |
| GO:0006285 | Base-excision repair, AP site formation | TAS | biological_process |
| GO:0006298 | Mismatch repair | TAS | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0019104 | DNA N-glycosylase activity | IEA | molecular_function |
| GO:0032405 | MutLalpha complex binding | IDA | molecular_function |
| GO:0032406 | MutLbeta complex binding | IDA | molecular_function |
| GO:0032407 | MutSalpha complex binding | IDA | molecular_function |
| GO:0032408 | MutSbeta complex binding | IDA | molecular_function |
| GO:0045007 | Depurination | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9666629915 | 0.1009732875 | 0.9999902473 | 0.6085233463 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0406027012 |
| GSE13712_SHEAR | Down | -0.6382908818 |
| GSE13712_STATIC | Down | -0.5596491740 |
| GSE19018 | Down | -0.0646829364 |
| GSE19899_A1 | Down | -0.3051929377 |
| GSE19899_A2 | Down | -0.0830791161 |
| PubMed_21979375_A1 | Up | 0.1018971223 |
| PubMed_21979375_A2 | Down | -0.0929942910 |
| GSE35957 | Down | -0.5033164979 |
| GSE36640 | Down | -0.3843616125 |
| GSE54402 | Up | 0.0649803674 |
| GSE9593 | Down | -0.4624698190 |
| GSE43922 | Up | 0.0486975967 |
| GSE24585 | Up | 0.1078602633 |
| GSE37065 | Down | -0.0969968339 |
| GSE28863_A1 | Down | -0.0621063412 |
| GSE28863_A2 | Down | -0.0279340945 |
| GSE28863_A3 | Up | 0.1198477003 |
| GSE28863_A4 | Up | 0.0613716930 |
| GSE48662 | Down | -0.1653745105 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25921542 | Accordingly, LPC provoked oxidative DNA injury, whereas the gene expressions of DNA repair enzyme (OGG1, MUTYH, MTH1) remained unchanged |
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