HCSGD entry for MUT

1. General information

Official gene symbolMUT
Entrez ID4594
Gene full namemethylmalonyl CoA mutase
Other gene symbolsMCM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004494Methylmalonyl-CoA mutase activityIEAmolecular_function
GO:0005739MitochondrionTAScellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006635Fatty acid beta-oxidationTASbiological_process
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0009235Cobalamin metabolic processTASbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0019626Short-chain fatty acid catabolic processTASbiological_process
GO:0031419Cobalamin bindingIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050667Homocysteine metabolic processIDAbiological_process
GO:0072341Modified amino acid bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98063377150.00639407700.99999024730.1630028019

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1593518941
GSE13712_SHEARDown-0.3491104091
GSE13712_STATICDown-0.4132203889
GSE19018Up0.0348144688
GSE19899_A1Down-0.9737628469
GSE19899_A2Down-0.8548789299
PubMed_21979375_A1Down-0.8213721303
PubMed_21979375_A2Down-0.7834688929
GSE35957Down-0.3647169358
GSE36640Down-0.2897667320
GSE54402Down-0.7069482570
GSE9593Up0.0730940950
GSE43922Down-0.6405658893
GSE24585Up0.2353329890
GSE37065Up0.0272613600
GSE28863_A1Up0.0145701747
GSE28863_A2Up0.2750916657
GSE28863_A3Down-1.2383990490
GSE28863_A4Down-0.3249126179
GSE48662Up0.0721940418

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CyanocobalaminDB00115 NUTR00004 | APRD00326 | EXPT00965
HydroxocobalaminDB00200 APRD01022

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020551ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT039809CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27651846Cells were seeded into 24-well plates with hydrogen peroxide added to cell medium and incubated at 37 degrees C + 5% CO2 for a 90-minute period [at 0, 300, 400 and 800 micromolar (MCM) hydrogen peroxide]
27651846Treatment with hydrogen peroxide reduced this level of cell proliferation significantly (to 52,167 cells at 400 MCM; to 49,263 cells at 800 MCM)
27651846Meanwhile, cells with a high level of positive senescence-indicator SA-Beta-Gal-positive staining was induced by hydrogen peroxide treatment (from a baseline level of 12% to 80% at 400 MCM and at 800 MCM)
22790201Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS
21160097The MCM (minichromosome maintenance protein) protein family was identified for the first time in budding yeast, Saccharomyces cerevisiae
21160097The subgroup consists of MCM proteins 2-9, that possess the characteristic ATPase domain (MCM box)
21160097There are also MCM1 and MCM10, which are important in DNA replication, but they do not possess the specific MCM box
21160097The main function of MCM proteins is cooperation with other factors in molecular mechanisms that form the replication fork and in regulation of DNA synthesis
21160097MCM proteins form a ring-shaped complex, which is activated when other factors are bound
21160097MCM 2-7 complex is one of the pre-replication factors
21160097Association of MCM 2-7 complex is a crucial moment initiating the replication fork
21160097MCM proteins play a role in maintaining genome integrity and prevent re-replication once per cell cycle
21160097Proliferating cells have high levels of MCM, whereas they are not detected in quiescent, differentiated or senescent cells
21160097The aim of this work is to summarize current knowledge about the role of MCM proteins in DNA replication and potential diagnostic markers of proliferating cancer cells
19001876In eukaryotic cells, MCM, the minichromosome maintenance proteins, form a heterohexamer during G(1) phase in the cell cycle and constitute a DNA helicase activity at the onset of replication
19001876MCM proteins are downregulated and dissociated from chromatin when cells exit the cell cycle
19001876MCM proteins are upregulated frequently in a variety of dysplastic and cancer cells
19001876To delineate the role of MCM in esophageal epithelial biology, we determined the MCM family gene expression during cellular senescence, immortalization, differentiation and apoptosis
19001876Epitope mapping of this MCM2-related fragment suggested the lack of amino- and carboxyl-terminal regions, including one of the putative nuclear localization signals and the ATPase domain, the MCM box
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