HCSGD entry for MTRR
1. General information
| Official gene symbol | MTRR |
|---|---|
| Entrez ID | 4552 |
| Gene full name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
| Other gene symbols | MSR cblE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0003958 | NADPH-hemoprotein reductase activity | IBA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006306 | DNA methylation | ISS | biological_process |
| GO:0006555 | Methionine metabolic process | TAS | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0009086 | Methionine biosynthetic process | IEA | biological_process |
| GO:0009235 | Cobalamin metabolic process | TAS | biological_process |
| GO:0010181 | FMN binding | IEA TAS | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0016709 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | IBA | molecular_function |
| GO:0016723 | Oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor | IDA | molecular_function |
| GO:0030586 | [methionine synthase] reductase activity | TAS | molecular_function |
| GO:0032259 | Methylation | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0046655 | Folic acid metabolic process | ISS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IDA TAS | molecular_function |
| GO:0050661 | NADP binding | TAS | molecular_function |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1430874815 | 0.7707751149 | 0.7577878471 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2867667144 |
| GSE13712_SHEAR | Up | 0.1403309290 |
| GSE13712_STATIC | Down | -0.0033107293 |
| GSE19018 | Down | -0.5727719208 |
| GSE19899_A1 | Up | 0.2893849117 |
| GSE19899_A2 | Up | 0.7506915481 |
| PubMed_21979375_A1 | Up | 0.3695823838 |
| PubMed_21979375_A2 | Up | 0.1213979703 |
| GSE35957 | Up | 0.2179950553 |
| GSE36640 | Down | -0.0083177818 |
| GSE54402 | Up | 0.2762129853 |
| GSE9593 | Down | -0.0869733216 |
| GSE43922 | Up | 0.3100456348 |
| GSE24585 | Up | 0.2019839028 |
| GSE37065 | Up | 0.0310017262 |
| GSE28863_A1 | Down | -0.1996523628 |
| GSE28863_A2 | Up | 0.2429163667 |
| GSE28863_A3 | Down | -0.4574095301 |
| GSE28863_A4 | Down | -0.0865808067 |
| GSE48662 | Down | -0.3098924218 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cyanocobalamin | DB00115 | NUTR00004 | APRD00326 | EXPT00965 |
| Hydroxocobalamin | DB00200 | APRD01022 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001613 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031186 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23270390 | Forty-five male Sprague-Dawley rats were categorised into four groups: maternally separated runners (MSR), maternally separated non-runners (MSnR), non-maternally separated runners (nMSR) and non-maternally separated non-runners (nMSnR) |
| 21784712 | Methionine sulfoxide reductase (Msr), a repair enzyme that reduces methionine sulfoxide residues in proteins damaged by oxidation, was also significantly upregulated (2 |
| 21784712 | In LCM-harvested senescent cells, Msr was significantly downregulated in senescent versus nonsenescent cells, a finding previously recognized in other types of senescent cells |
| 21784712 | CONCLUSIONS: Novel data showed that significant gene expression patterns are present in the human annulus related to mitochondrial dysfunction; changes were identified in important genes involving apoptosis, eNOS and Msr expressions, and solute carrier genes |
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