HCSGD entry for MTNR1A

1. General information

Official gene symbolMTNR1A
Entrez ID4543
Gene full namemelatonin receptor 1A
Other gene symbolsMEL-1A-R MT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007617Mating behaviorTASbiological_process
GO:0007623Circadian rhythmTASbiological_process
GO:0008502Melatonin receptor activityIEAmolecular_function
GO:0030828Positive regulation of cGMP biosynthetic processIDAbiological_process
GO:0042562Hormone bindingIPImolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0097159Organic cyclic compound bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31856073860.93573411340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1486037259
GSE13712_SHEARUp0.0083733870
GSE13712_STATICUp0.2238072109
GSE19018Up0.0718809670
GSE19899_A1Up0.0027811420
GSE19899_A2Up0.2539561345
PubMed_21979375_A1Up0.0553295738
PubMed_21979375_A2Down-0.0858784927
GSE35957Up0.2901549752
GSE36640Up0.2278749765
GSE54402Up0.0245600325
GSE9593Up0.0282379243
GSE43922Up0.0219377356
GSE24585Up0.5019679847
GSE37065Down-0.0307640146
GSE28863_A1Up0.0716103903
GSE28863_A2Down-0.0074904279
GSE28863_A3Up0.1605625616
GSE28863_A4Up0.1585940692
GSE48662Down-0.0549031279

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RamelteonDB00980 APRD01213
MelatoninDB01065 APRD00742 | DB08189
VEC-162DB05359 -
AgomelatineDB06594 -
TasimelteonDB09071 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.