HCSGD entry for NUDT1
1. General information
| Official gene symbol | NUDT1 |
|---|---|
| Entrez ID | 4521 |
| Gene full name | nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
| Other gene symbols | MTH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006184 | GTP catabolic process | IDA | biological_process |
| GO:0006195 | Purine nucleotide catabolic process | IDA | biological_process |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006203 | DGTP catabolic process | IDA IEA | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006298 | Mismatch repair | IC | biological_process |
| GO:0006979 | Response to oxidative stress | TAS | biological_process |
| GO:0008413 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | IDA IEA | molecular_function |
| GO:0030515 | SnoRNA binding | IEA ISS | molecular_function |
| GO:0034656 | Nucleobase-containing small molecule catabolic process | TAS | biological_process |
| GO:0035539 | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | IDA | molecular_function |
| GO:0042262 | DNA protection | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046061 | DATP catabolic process | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0047693 | ATP diphosphatase activity | IDA | molecular_function |
| GO:0050072 | M7G(5')pppN diphosphatase activity | ISS | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9964333118 | 0.0012431519 | 0.9999902473 | 0.0671438525 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3427290559 |
| GSE13712_SHEAR | Down | -0.4328583170 |
| GSE13712_STATIC | Down | -0.6702603207 |
| GSE19018 | Down | -0.1342166938 |
| GSE19899_A1 | Down | -1.0857768631 |
| GSE19899_A2 | Down | -1.8846410938 |
| PubMed_21979375_A1 | Down | -1.4800831065 |
| PubMed_21979375_A2 | Down | -2.5144975705 |
| GSE35957 | Down | -1.5067932004 |
| GSE36640 | Down | -1.8909467800 |
| GSE54402 | Down | -0.4551574625 |
| GSE9593 | Down | -0.3535941852 |
| GSE43922 | Down | -0.0198038789 |
| GSE24585 | Down | -0.3457239486 |
| GSE37065 | Down | -0.0748243246 |
| GSE28863_A1 | Down | -0.2537735091 |
| GSE28863_A2 | Up | 0.0089326069 |
| GSE28863_A3 | Up | 0.0359579953 |
| GSE28863_A4 | Up | 0.0940790239 |
| GSE48662 | Down | -0.0073260582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25921542 | Accordingly, LPC provoked oxidative DNA injury, whereas the gene expressions of DNA repair enzyme (OGG1, MUTYH, MTH1) remained unchanged |
| 22790201 | Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS |
| 22790201 | We have recently shown that oncogenic RAS-induced DNA damage and attendant premature senescence can be prevented by overexpressing human MutT Homolog 1 (MTH1), the major mammalian detoxifier of the oxidized DNA precursor, 8-oxo-dGTP |
| 22790201 | Within this context, we will discuss the implications of MTH1 upregulation in oncogenic RAS-sustaining cells as a beneficial adaptive change that inhibits ROS-mediated cell senescence and participates in the maintenance of ROS-associated tumor-promoting mechanisms |
| 22790201 | Accordingly, targeting MTH1 in RAS-transformed tumor cells will not only induce proliferative defects but also potentially enhance therapeutic cytotoxicity by shifting cellular response away from pro-survival mechanisms |
| 19118192 | Suppression of MTH1 expression, which hydrolyzes 8-oxo-dGTP, was accompanied by increased total cellular 8-oxoguanine levels and caused early-passage primary and telomerase-immortalized human skin fibroblasts to rapidly undergo senescence, doing so without altering cellular ROS levels |
Entries Per Page
Displaying Page of
