HCSGD entry for MTAP

1. General information

Official gene symbolMTAP
Entrez ID4507
Gene full namemethylthioadenosine phosphorylase
Other gene symbolsBDMF DMSFH DMSMFH LGMBF MSAP c86fus
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000096Sulfur amino acid metabolic processTASbiological_process
GO:0003824Catalytic activityIEAmolecular_function
GO:0004645Phosphorylase activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006139Nucleobase-containing compound metabolic processTASbiological_process
GO:0006166Purine ribonucleoside salvageIEAbiological_process
GO:0006595Polyamine metabolic processTASbiological_process
GO:0006738Nicotinamide riboside catabolic processIDAbiological_process
GO:0009116Nucleoside metabolic processIEAbiological_process
GO:0017061S-methyl-5-thioadenosine phosphorylase activityIEA TASmolecular_function
GO:0019509L-methionine salvage from methylthioadenosineIEA TASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01553819760.94259895140.30957416921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1686267761
GSE13712_SHEARUp0.7761425311
GSE13712_STATICUp0.4392514347
GSE19018Down-0.5622169545
GSE19899_A1Up0.5048771887
GSE19899_A2Up0.6287996946
PubMed_21979375_A1Up1.4126145605
PubMed_21979375_A2Up0.1459427636
GSE35957Down-0.1426805583
GSE36640Down-0.4604433977
GSE54402Up0.8129926967
GSE9593Down-0.1176921493
GSE43922Up0.7901188786
GSE24585Down-0.3012643550
GSE37065Up0.1571819876
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.3328997555

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AdenineDB00173 NUTR00012 | EXPT00520
(1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-RibitolDB02158 EXPT02247
FormycinDB02281 EXPT01453
5'-Deoxy-5'-MethylthioadenosineDB02282 EXPT02241
5'-Deoxy-5'-(Methylthio)-TubercidinDB02933 EXPT02244

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT000961Western blot//Northern blot//qRT-PCR//Luciferase reporter assayFunctional MTI19013014
hsa-miR-21-5pMIMAT0000076MIRT000961MicroarrayFunctional MTI (Weak)18591254
hsa-miR-155-5pMIMAT0000646MIRT020610ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT025319SequencingFunctional MTI (Weak)20371350
hsa-miR-34a-5pMIMAT0000255MIRT025319ProteomicsFunctional MTI (Weak)21566225
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT00000761hsa-miR-2119013014
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.