HCSGD entry for MST1
1. General information
| Official gene symbol | MST1 |
|---|---|
| Entrez ID | 4485 |
| Gene full name | macrophage stimulating 1 (hepatocyte growth factor-like) |
| Other gene symbols | D3F15S2 DNF15S2 HGFL MSP NF15S2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0030317 | Sperm motility | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8939232058 | 0.1589293378 | 0.9999902473 | 0.7700200920 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0502620670 |
| GSE13712_SHEAR | Down | -0.9351788751 |
| GSE13712_STATIC | Down | -0.6457336505 |
| GSE19018 | Up | 0.0658446545 |
| GSE19899_A1 | Down | -0.0357937428 |
| GSE19899_A2 | Up | 0.0175157798 |
| PubMed_21979375_A1 | Down | -0.9733346049 |
| PubMed_21979375_A2 | Down | -0.1292851818 |
| GSE35957 | Down | -0.0201984772 |
| GSE36640 | Up | 0.5026499311 |
| GSE54402 | Down | -0.3623664530 |
| GSE9593 | Down | -0.1362137300 |
| GSE43922 | Up | 0.0214473926 |
| GSE24585 | Down | -0.0160475071 |
| GSE37065 | Up | 0.0265347306 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.4897092969 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025230 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26763397 | It also activated the mammalian Ste20-like protein kinase 1 (MST1); however the serine/threonine kinase Akt was downregulated |
| 26763397 | Forkhead box O (FOXO) transcription factors are activated through phosphorylation by MST1 under stress conditions |
| 24334454 | Enhanced RASSF4 expression promoted cell cycle progression, senescence evasion, and tumorigenesis through inhibition of the Hippo pathway tumor suppressor MST1 |
| 24334454 | Additionally, we identify a mechanism used by PAX3-FOXO1 to inhibit MST1 signaling and promote tumorigenesis in aRMS |
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