HCSGD entry for MSN

1. General information

Official gene symbolMSN
Entrez ID4478
Gene full namemoesin
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001931UropodIEAcellular_component
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003779Actin bindingIEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005902MicrovillusIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006928Cellular component movementTASbiological_process
GO:0007159Leukocyte cell-cell adhesionIEPbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019898Extrinsic component of membraneIEAcellular_component
GO:0019901Protein kinase bindingIPImolecular_function
GO:0022614Membrane to membrane dockingIEPbiological_process
GO:0030175FilopodiumIDAcellular_component
GO:0031528Microvillus membraneIEAcellular_component
GO:0045177Apical part of cellIDAcellular_component
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0050900Leukocyte migrationIEPbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:2000401Regulation of lymphocyte migrationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23245700010.90282604000.91595413171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0911279013
GSE13712_SHEARUp0.0520198024
GSE13712_STATICUp0.1266696211
GSE19018Up0.0464508988
GSE19899_A1Up0.0601240644
GSE19899_A2Up0.0685418869
PubMed_21979375_A1Up1.1944264396
PubMed_21979375_A2Up0.1522905039
GSE35957Up0.1020016432
GSE36640Up0.3298704348
GSE54402Up0.2383600692
GSE9593Up0.2113471090
GSE43922Up0.1999303687
GSE24585Down-0.2884945869
GSE37065Up0.0981410180
GSE28863_A1Down-0.0228190540
GSE28863_A2Down-0.0073486626
GSE28863_A3Down-0.1190284712
GSE28863_A4Up0.0778498301
GSE48662Down-0.2862451252

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT006433Immunoblot//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21501518
hsa-miR-192-5pMIMAT0000222MIRT004153MicroarrayFunctional MTI (Weak)16822819
hsa-miR-192-5pMIMAT0000222MIRT004153MicroarrayFunctional MTI (Weak)19074876
hsa-miR-133a-3pMIMAT0000427MIRT006680qRT-PCR//Western blotFunctional MTI22266319
hsa-miR-124-3pMIMAT0000422MIRT022862Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024781MicroarrayFunctional MTI (Weak)19074876
hsa-miR-615-3pMIMAT0003283MIRT040059CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052198CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22897574In addition, the expressions of moesin and rho GTP dissociation inhibitor, additional age-related candidate biomarkers, were decreased by PON1 knock-down in HDMECs
20376899Knockdown of moesin expression accelerates cellular senescence of human dermal microvascular endothelial cells
20376899Recently, the expression of moesin was found to be decreased in elderly human dermal microvascular endothelial cells (HDMECs), and an association between moesin and senescence has been suggested
20376899MATERIALS AND METHODS: To study the effects of decreased moesin expression on cellular senescence and metabolism, HDMECs were transfected with short hairpin-RNA (shRNA) lentivirus to silence moesin gene expression
20376899RESULTS: Using shRNAlentivirus, moesin knock-down HDMECs developed characteristics associated with aging and expressed senescence associated-beta-galactosidase during early passages
20376899Human skin tissue from elderly persons showed decreased moesin expression and increased p16 expression
20376899CONCLUSION: These findings suggest that there is a functional association between moesin expression and cellular senescence
20376899Further study of the functional mechanism of moesin in the cytoskeleton and cellular senescence is needed
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