HCSGD entry for ASS1

1. General information

Official gene symbolASS1
Entrez ID445
Gene full nameargininosuccinate synthase 1
Other gene symbolsASS CTLN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000050Urea cycleIEA TASbiological_process
GO:0000053Argininosuccinate metabolic processIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0004055Argininosuccinate synthase activityEXP IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006526Arginine biosynthetic processIEAbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007494Midgut developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010046Response to mycotoxinIEAbiological_process
GO:0015643Toxic substance bindingIEAmolecular_function
GO:0032355Response to estradiolIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043204PerikaryonIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0060416Response to growth hormoneIEAbiological_process
GO:0060539Diaphragm developmentIEAbiological_process
GO:0070852Cell body fiberIEAcellular_component
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:0071242Cellular response to ammonium ionIEAbiological_process
GO:0071320Cellular response to cAMPIEAbiological_process
GO:0071346Cellular response to interferon-gammaIEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071377Cellular response to glucagon stimulusIEAbiological_process
GO:0071400Cellular response to oleic acidIEAbiological_process
GO:0071418Cellular response to amine stimulusIEAbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01371349490.03819950230.29226140780.3680267570

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3486132221
GSE13712_SHEARDown-3.1387598315
GSE13712_STATICDown-1.3761175234
GSE19018Down-0.3125873357
GSE19899_A1Up0.4933242715
GSE19899_A2Up1.5771961934
PubMed_21979375_A1Up1.8870362357
PubMed_21979375_A2Up0.9301807837
GSE35957Up0.2249377839
GSE36640Down-1.2460000451
GSE54402Up0.0137440341
GSE9593Up0.6460241500
GSE43922Down-0.1859943587
GSE24585Up0.3847956059
GSE37065Down-0.0999618687
GSE28863_A1Down-0.8665187772
GSE28863_A2Up0.0379562043
GSE28863_A3Up0.2286264100
GSE28863_A4Up0.1108951126
GSE48662Up0.2879653175

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-ArginineDB00125 NUTR00014
L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
L-Aspartic AcidDB00128 NUTR00016 | EXPT01823

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-324-5pMIMAT0000761MIRT043101CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049535CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050346CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19409979These genes included argininosuccinate synthetase 1, which was determined to be critical for both basal and LSS-induced NO production in young HUVECs
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