HCSGD entry for MSH2
1. General information
| Official gene symbol | MSH2 |
|---|---|
| Entrez ID | 4436 |
| Gene full name | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) |
| Other gene symbols | COCA1 FCC1 HNPCC HNPCC1 LCFS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | IBA | cellular_component |
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0000400 | Four-way junction DNA binding | IDA | molecular_function |
| GO:0000403 | Y-form DNA binding | IBA | molecular_function |
| GO:0000404 | Loop DNA binding | IBA | molecular_function |
| GO:0000406 | Double-strand/single-strand DNA junction binding | IBA | molecular_function |
| GO:0000710 | Meiotic mismatch repair | IBA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IDA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0006119 | Oxidative phosphorylation | IEA | biological_process |
| GO:0006200 | ATP catabolic process | IBA IDA | biological_process |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006298 | Mismatch repair | IDA IEA IGI | biological_process |
| GO:0006301 | Postreplication repair | IDA | biological_process |
| GO:0006302 | Double-strand break repair | IBA IEA | biological_process |
| GO:0006311 | Meiotic gene conversion | IBA | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0007281 | Germ cell development | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008094 | DNA-dependent ATPase activity | IBA | molecular_function |
| GO:0008340 | Determination of adult lifespan | IEA | biological_process |
| GO:0008584 | Male gonad development | IEA ISS | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
| GO:0010165 | Response to X-ray | IBA IEA ISS | biological_process |
| GO:0010224 | Response to UV-B | IBA IEA ISS | biological_process |
| GO:0016446 | Somatic hypermutation of immunoglobulin genes | IBA IEA | biological_process |
| GO:0016447 | Somatic recombination of immunoglobulin gene segments | ISS | biological_process |
| GO:0016887 | ATPase activity | IDA IEA | molecular_function |
| GO:0019237 | Centromeric DNA binding | IEA | molecular_function |
| GO:0019724 | B cell mediated immunity | ISS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030183 | B cell differentiation | IEA ISS | biological_process |
| GO:0030983 | Mismatched DNA binding | IDA IEA | molecular_function |
| GO:0031573 | Intra-S DNA damage checkpoint | IBA IEA | biological_process |
| GO:0032137 | Guanine/thymine mispair binding | IDA IMP | molecular_function |
| GO:0032139 | Dinucleotide insertion or deletion binding | IDA | molecular_function |
| GO:0032142 | Single guanine insertion binding | IDA | molecular_function |
| GO:0032143 | Single thymine insertion binding | IDA | molecular_function |
| GO:0032181 | Dinucleotide repeat insertion binding | IDA | molecular_function |
| GO:0032301 | MutSalpha complex | IDA IEA | cellular_component |
| GO:0032302 | MutSbeta complex | IDA IEA | cellular_component |
| GO:0032357 | Oxidized purine DNA binding | IDA | molecular_function |
| GO:0032405 | MutLalpha complex binding | IDA | molecular_function |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IBA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA ISS | biological_process |
| GO:0043531 | ADP binding | IDA | molecular_function |
| GO:0043570 | Maintenance of DNA repeat elements | IMP | biological_process |
| GO:0045128 | Negative regulation of reciprocal meiotic recombination | IBA | biological_process |
| GO:0045190 | Isotype switching | IBA IEA ISS | biological_process |
| GO:0045910 | Negative regulation of DNA recombination | IDA IEA ISS | biological_process |
| GO:0051096 | Positive regulation of helicase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9851999962 | 0.0007780441 | 0.9999902473 | 0.0524322335 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5225436999 |
| GSE13712_SHEAR | Down | -0.8590921378 |
| GSE13712_STATIC | Down | -0.5963084350 |
| GSE19018 | Down | -0.3419481884 |
| GSE19899_A1 | Down | -0.5433588576 |
| GSE19899_A2 | Down | -1.9656245672 |
| PubMed_21979375_A1 | Up | 0.1370433947 |
| PubMed_21979375_A2 | Down | -2.1403900991 |
| GSE35957 | Down | -1.3703049393 |
| GSE36640 | Down | -1.9169628437 |
| GSE54402 | Down | -0.2891392730 |
| GSE9593 | Down | -0.9219133550 |
| GSE43922 | Down | -0.6235427232 |
| GSE24585 | Down | -0.2726016497 |
| GSE37065 | Down | -0.2525316331 |
| GSE28863_A1 | Up | 0.1889450879 |
| GSE28863_A2 | Up | 1.0899120745 |
| GSE28863_A3 | Down | -0.3728047376 |
| GSE28863_A4 | Down | -0.1230147507 |
| GSE48662 | Down | -0.5900953992 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT000460 | Luciferase reporter assay//Western blot//Northern blot | Functional MTI | 20351277 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT000879 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000880 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005429 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 21078976 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005429 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21047769 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005429 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1 | MIMAT0000416 | MIRT023691 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027251 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047085 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18567801 | Western blot and immunohistochemistry analysis revealed that hMSH2 and MSH6 protein (MutS alpha complex), which is a known key component in the MMR pathway, is markedly down-regulated in senescent cells |
| 18567801 | Semiquantitative reverse transcription-PCR analysis exhibited that MSH2 mRNA level is reduced in senescent cells |
| 18567801 | In addition, a decrease in E2F transcriptional activity in senescent cells was found to be crucial for MSH2 suppression |
| 18567801 | E2F1 small interfering RNA expression reduced hMSH2 expression and MMR activity in young human primary fibroblast cells |
| 18567801 | Importantly, expression of E2F1 in quiescent cells restored the MSH2 expression as well as MMR activity, whereas E2F1-infected senescent cells exhibited no restoration of MSH2 expression and MMR activity |
| 18567801 | These results indicate that the suppression of E2F1 transcriptional activity in senescent cells lead to stable repression of MSH2, followed by a induction of MutS alpha dysfunction, which results in a reduced cellular MMR capacity in senescent cells |
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