HCSGD entry for MTHFD2L
1. General information
| Official gene symbol | MTHFD2L |
|---|---|
| Entrez ID | 441024 |
| Gene full name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000105 | Histidine biosynthetic process | IEA | biological_process |
| GO:0004329 | Formate-tetrahydrofolate ligase activity | IBA | molecular_function |
| GO:0004477 | Methenyltetrahydrofolate cyclohydrolase activity | IBA | molecular_function |
| GO:0004487 | Methylenetetrahydrofolate dehydrogenase (NAD+) activity | IBA | molecular_function |
| GO:0004488 | Methylenetetrahydrofolate dehydrogenase (NADP+) activity | IBA IEA | molecular_function |
| GO:0005739 | Mitochondrion | IBA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IBA | cellular_component |
| GO:0006164 | Purine nucleotide biosynthetic process | IEA | biological_process |
| GO:0006730 | One-carbon metabolic process | IBA | biological_process |
| GO:0009086 | Methionine biosynthetic process | IEA | biological_process |
| GO:0009396 | Folic acid-containing compound biosynthetic process | IEA | biological_process |
| GO:0035999 | Tetrahydrofolate interconversion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0174917480 | 0.8576843091 | 0.3251440141 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5006105358 |
| GSE13712_SHEAR | Down | -0.0189699897 |
| GSE13712_STATIC | Up | 0.0693042952 |
| GSE19018 | Down | -0.0916565049 |
| GSE19899_A1 | Up | 0.2834965172 |
| GSE19899_A2 | Up | 1.0505003421 |
| PubMed_21979375_A1 | Up | 1.8650784247 |
| PubMed_21979375_A2 | Up | 0.6868383244 |
| GSE35957 | Down | -0.1994977644 |
| GSE36640 | Down | -0.2895369987 |
| GSE54402 | Up | 0.8788566253 |
| GSE9593 | Down | -0.3189790284 |
| GSE43922 | Up | 1.1908607940 |
| GSE24585 | Up | 0.0795433974 |
| GSE37065 | Up | 0.5590251025 |
| GSE28863_A1 | Down | -0.0802622209 |
| GSE28863_A2 | Up | 0.0611063534 |
| GSE28863_A3 | Down | -0.2515759350 |
| GSE28863_A4 | Down | -0.3202694834 |
| GSE48662 | Down | -0.0168775614 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-96-5p | MIMAT0000095 | MIRT027905 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
