HCSGD entry for EIF2AK4

1. General information

Official gene symbolEIF2AK4
Entrez ID440275
Gene full nameeukaryotic translation initiation factor 2 alpha kinase 4
Other gene symbolsGCN2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIEA ISSmolecular_function
GO:0004694Eukaryotic translation initiation factor 2alpha kinase activityISSmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006446Regulation of translational initiationISSbiological_process
GO:0006468Protein phosphorylationISSbiological_process
GO:0009267Cellular response to starvationIEAbiological_process
GO:0017148Negative regulation of translationIEAbiological_process
GO:0022626Cytosolic ribosomeISScellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043558Regulation of translational initiation in response to stressIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44300806200.11489542570.99999024730.6492405539

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0451044488
GSE13712_SHEARUp0.2316085847
GSE13712_STATICUp0.2118101800
GSE19018Up0.9973950738
GSE19899_A1Down-0.1795478475
GSE19899_A2Up0.3378751476
PubMed_21979375_A1Down-0.5562817211
PubMed_21979375_A2Down-0.1589610486
GSE35957Down-0.1452847405
GSE36640Down-0.4502470037
GSE54402Down-0.2179232555
GSE9593Down-0.1580091848
GSE43922Down-0.0177154229
GSE24585Down-0.3676421480
GSE37065Down-0.3019334821
GSE28863_A1Up0.0293149778
GSE28863_A2Up0.3480524804
GSE28863_A3Down-0.8012205141
GSE28863_A4Up0.1718372065
GSE48662Down-0.2084038934

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.