HCSGD entry for MRE11A

1. General information

Official gene symbolMRE11A
Entrez ID4361
Gene full nameMRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Other gene symbolsATLD HNGS1 MRE11 MRE11B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000014Single-stranded DNA endodeoxyribonuclease activityTASmolecular_function
GO:0000019Regulation of mitotic recombinationTASbiological_process
GO:0000724Double-strand break repair via homologous recombinationTASbiological_process
GO:0000737DNA catabolic process, endonucleolyticTASbiological_process
GO:0000781Chromosome, telomeric regionIDAcellular_component
GO:0003677DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingTASmolecular_function
GO:0004003ATP-dependent DNA helicase activityIMPmolecular_function
GO:0004518Nuclease activityTASmolecular_function
GO:0004519Endonuclease activityIEAmolecular_function
GO:0004520Endodeoxyribonuclease activityTASmolecular_function
GO:0004527Exonuclease activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006200ATP catabolic processIMPbiological_process
GO:0006259DNA metabolic processIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIEA TASbiological_process
GO:0006303Double-strand break repair via nonhomologous end joiningTASbiological_process
GO:0006308DNA catabolic processTASbiological_process
GO:0006310DNA recombinationTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007004Telomere maintenance via telomeraseTASbiological_process
GO:0007062Sister chromatid cohesionIMPbiological_process
GO:0007095Mitotic G2 DNA damage checkpointIEAbiological_process
GO:0007126MeiosisIEAbiological_process
GO:0007129SynapsisIEAbiological_process
GO:0007131Reciprocal meiotic recombinationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008283Cell proliferationIEAbiological_process
GO:00084083'-5' exonuclease activityTASmolecular_function
GO:0030145Manganese ion bindingIEAmolecular_function
GO:0030870Mre11 complexIDA NAScellular_component
GO:0031573Intra-S DNA damage checkpointIEAbiological_process
GO:0031954Positive regulation of protein autophosphorylationIDAbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0032876Negative regulation of DNA endoreduplicationIMPbiological_process
GO:0033674Positive regulation of kinase activityIDAbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93960496940.03885096690.99999024730.3715829578

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1337334343
GSE13712_SHEARDown-0.0747933327
GSE13712_STATICDown-0.1901926160
GSE19018Down-0.0124871743
GSE19899_A1Down-0.2345659705
GSE19899_A2Down-0.7091762287
PubMed_21979375_A1Down-0.3349150083
PubMed_21979375_A2Down-0.6386615060
GSE35957Down-0.2146845913
GSE36640Down-0.8559152703
GSE54402Down-0.2869213286
GSE9593Down-0.1890137206
GSE43922Down-0.4072761895
GSE24585Up0.1647310184
GSE37065Down-0.2251455547
GSE28863_A1Up0.2703124799
GSE28863_A2Up0.8191176373
GSE28863_A3Up0.0247376381
GSE28863_A4Up0.0187702505
GSE48662Down-0.2809798838

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-210-3pMIMAT0000267MIRT003916Western blotNon-Functional MTI19141645
hsa-miR-373-3pMIMAT0000726MIRT003919Western blotNon-Functional MTI19141645
hsa-miR-375MIMAT0000728MIRT019709MicroarrayFunctional MTI (Weak)20215506
hsa-miR-1MIMAT0000416MIRT023658ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT025337ProteomicsFunctional MTI (Weak)21566225
hsa-miR-30a-5pMIMAT0000087MIRT028405ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26209132Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks
26209132We now show that inhibition of MRE11 3'-5' exonuclease activity with Mirin reduces the frequency of large deletions and GCRs at both interstitial and subtelomeric DSBs, but has little effect on the frequency of small deletions
25524056METHODS AND RESULTS: Human atherosclerotic plaque VSMCs showed increased expression of multiple DNA damage response proteins in vitro and in vivo, particularly the MRE11/RAD50/NBS1 complex that senses DSB repair
24529708TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres
24529708At uncapped telomeres, LSD1 associates with MRE11, one of the nucleases implicated in the processing of 3' telomeric G overhangs, and we show that LSD1 is required for efficient removal of these structures
24529708Furthermore, LSD1 enhances the nuclease activity of MRE11 in vitro
24529708Our data indicate that recruitment of LSD1 to deprotected telomeres requires MRE11 and is promoted by TERRA
24529708LSD1 stimulates MRE11 catalytic activity and nucleolytic processing of uncapped telomeres
19442255It is known that telomere length maintenance in ALT+ cells is dependent on the MRN [MRE11 (meiotic recombination 11)-Rad50-NBS1 (Nijmegen breakage syndrome 1)] complex, but knowledge of the role of other genes, including the Werner's (WRN) and Bloom's (BLM) syndrome DNA helicase genes, is still limited
17202845Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
17202845Our data presented here show that among the DSB repair proteins tested, only the expression of Ku70 and Mre11 showed statistically significant age-dependent changes in human lymphocytes
17202845Furthermore, we found that expressions of Ku70 and Mre11 are statistically correlated, which indicate that the function of Ku70 and Mre11 may be related
17202845Taken together, our data show, for the first time, that Ku70 and Mre11 may represent new biomarkers for aging and further suggest that maintenance of higher expression of Ku70 and Mre11 may be responsible for keeping longer life span observed in the longevity group
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