HCSGD entry for MPL
1. General information
| Official gene symbol | MPL |
|---|---|
| Entrez ID | 4352 |
| Gene full name | myeloproliferative leukemia virus oncogene |
| Other gene symbols | C-MPL CD110 MPLV THCYT2 TPOR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004896 | Cytokine receptor activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0032642 | Regulation of chemokine production | IEA | biological_process |
| GO:0048872 | Homeostasis of number of cells | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6713455948 | 0.9027337259 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0001677038 |
| GSE13712_SHEAR | Down | -0.0496914727 |
| GSE13712_STATIC | Up | 0.0514138638 |
| GSE19018 | Down | -0.1444774282 |
| GSE19899_A1 | Up | 0.0126815536 |
| GSE19899_A2 | Down | -0.0651206726 |
| PubMed_21979375_A1 | Down | -0.0275811443 |
| PubMed_21979375_A2 | Down | -0.0441907002 |
| GSE35957 | Up | 0.2349365958 |
| GSE36640 | Up | 0.0323570554 |
| GSE54402 | Down | -0.0216720565 |
| GSE9593 | Up | 0.0877740949 |
| GSE43922 | Up | 0.0241151990 |
| GSE24585 | Up | 0.0499899924 |
| GSE37065 | Up | 0.0525018055 |
| GSE28863_A1 | Up | 0.0006114036 |
| GSE28863_A2 | Up | 0.0060734116 |
| GSE28863_A3 | Up | 0.3164529469 |
| GSE28863_A4 | Up | 0.1757708621 |
| GSE48662 | Up | 0.0044997942 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-708-3p | MIMAT0004927 | MIRT006410 | Luciferase reporter assay//Western blot | Functional MTI | 20445018 |
| hsa-miR-151a-5p | MIMAT0004697 | MIRT006409 | Luciferase reporter assay//Western blot | Functional MTI | 20445018 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT006406 | Luciferase reporter assay | Non-Functional MTI | 20445018 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT006407 | Luciferase reporter assay | Non-Functional MTI | 20445018 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT006404 | Luciferase reporter assay | Non-Functional MTI | 20445018 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT006405 | Luciferase reporter assay | Non-Functional MTI | 20445018 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT006403 | Luciferase reporter assay | Non-Functional MTI | 20445018 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT006402 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20445018 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT006408 | Luciferase reporter assay | Non-Functional MTI | 20445018 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
