HCSGD entry for MMP16
1. General information
| Official gene symbol | MMP16 |
|---|---|
| Entrez ID | 4325 |
| Gene full name | matrix metallopeptidase 16 (membrane-inserted) |
| Other gene symbols | C8orf57 MMP-X2 MT-MMP2 MT-MMP3 MT3-MMP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030574 | Collagen catabolic process | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4340741347 | 0.0372422058 | 0.9999902473 | 0.3635949926 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3500636912 |
| GSE13712_SHEAR | Down | -0.3254463269 |
| GSE13712_STATIC | Up | 0.1268759706 |
| GSE19018 | Down | -0.4390749646 |
| GSE19899_A1 | Up | 0.0586097470 |
| GSE19899_A2 | Up | 0.1349640305 |
| PubMed_21979375_A1 | Up | 0.3567722309 |
| PubMed_21979375_A2 | Down | -0.3351789962 |
| GSE35957 | Down | -0.6203686206 |
| GSE36640 | Down | -0.0727409552 |
| GSE54402 | Up | 0.9589774757 |
| GSE9593 | Down | -0.1511781253 |
| GSE43922 | Up | 0.2861651656 |
| GSE24585 | Up | 0.0777190821 |
| GSE37065 | Down | -0.2507796537 |
| GSE28863_A1 | Down | -0.3144094449 |
| GSE28863_A2 | Down | -0.5065813167 |
| GSE28863_A3 | Down | -1.2188869107 |
| GSE28863_A4 | Down | -0.1781956250 |
| GSE48662 | Up | 0.0306613264 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-146b-5p | MIMAT0002809 | MIRT004887 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19265686 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT004978 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19524507 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146b-5p | MIMAT0002809 | 1 | hsa-miR-146b-5p | 19265686 | |||
| hsa-miR-146b-5p | MIMAT0002809 | 2 | hsa-miR-146b-5p | 19265686 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
