HCSGD entry for MMP14
1. General information
| Official gene symbol | MMP14 |
|---|---|
| Entrez ID | 4323 |
| Gene full name | matrix metallopeptidase 14 (membrane-inserted) |
| Other gene symbols | 1 MMP-14 MMP-X1 MT-MMP MT-MMP 1 MT1-MMP MT1MMP MTMMP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001541 | Ovarian follicle development | IEA | biological_process |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001935 | Endothelial cell proliferation | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0016504 | Peptidase activator activity | IEA | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030307 | Positive regulation of cell growth | IDA | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0031638 | Zymogen activation | IEA | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0043615 | Astrocyte cell migration | IEA | biological_process |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IEA | biological_process |
| GO:0048771 | Tissue remodeling | IEA | biological_process |
| GO:0051895 | Negative regulation of focal adhesion assembly | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0017332700 | 0.8576592303 | 0.1112717073 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8160157485 |
| GSE13712_SHEAR | Down | -0.3384680561 |
| GSE13712_STATIC | Up | 0.0832546617 |
| GSE19018 | Up | 0.3733249122 |
| GSE19899_A1 | Up | 0.6188457571 |
| GSE19899_A2 | Up | 1.6124236570 |
| PubMed_21979375_A1 | Up | 1.0253340420 |
| PubMed_21979375_A2 | Down | -0.7542383145 |
| GSE35957 | Up | 0.9367156894 |
| GSE36640 | Down | -0.1338126865 |
| GSE54402 | Up | 1.2091520897 |
| GSE9593 | Up | 1.2325314205 |
| GSE43922 | Up | 1.0246261917 |
| GSE24585 | Up | 0.1417777105 |
| GSE37065 | Up | 0.2108391224 |
| GSE28863_A1 | Up | 0.2704078294 |
| GSE28863_A2 | Up | 0.5480784106 |
| GSE28863_A3 | Down | -0.3152330797 |
| GSE28863_A4 | Up | 0.0470149346 |
| GSE48662 | Down | -0.7256306200 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016970 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT021533 | Reporter assay;Microarray | Functional MTI | 21351259 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25991604 | MT1-MMP (MMP14) is a collagenolytic enzyme located at the cell surface and implicated in extracellular matrix (ECM) remodeling |
| 25991604 | Mmp14(-/-) mice present dwarfism, bone abnormalities, and premature death |
| 25991604 | We demonstrate herein that the loss of MT1-MMP also causes cardiac defects and severe metabolic changes, and alters the cytoskeleton and the nuclear lamina structure |
| 25991604 | Moreover, the absence of MT1-MMP induces a senescent phenotype characterized by up-regulation of p16(INK4a) and p21(CIP1/WAF) (1), increased activity of senescence-associated beta-galactosidase, generation of a senescence-associated secretory phenotype, and somatotroph axis alterations |
| 25991604 | Consistent with the role of retinoic acid signaling in nuclear lamina stabilization, treatment of Mmp14(-/-) mice with all-trans retinoic acid reversed the nuclear lamina alterations, partially rescued the cell senescence phenotypes, ameliorated the pathological defects in bone, skin, and heart, and extended their life span |
| 23904371 | And QDs probing showed MT1-MMP was strongly expressed in the invadopodia |
| 20407016 | Vascular endothelial cells produce considerable amounts of matrix metalloproteinases (MMP), including MMP-2, MMP-9, and membrane type 1 (MT1)-MMP |
| 20407016 | A glycosylphosphatidylinositol-anchored glycoprotein, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), has been shown to attenuate MMP-2 maturation by directly interacting with MT1-MMP |
| 12883667 | The invasive potential of Ad-p16 transduced cells was evaluated using a Matrigel invasion assay, and trimolecular complex (MMP-2/MT1-MMP/TIMP-2) synthesis was proven by zymography and Western blotting |
| 12883667 | However, we were unable to demonstrate any differences in the constitutive productions and secretions of MMP-2, MT1-MMP, and TIMP-2, among the mock-treated, Ad-lacZ-transduced, and Ad-p16-transduced cells |
Entries Per Page
Displaying Page of
