HCSGD entry for MMP11

1. General information

Official gene symbolMMP11
Entrez ID4320
Gene full namematrix metallopeptidase 11 (stromelysin 3)
Other gene symbolsSL-3 ST3 STMY3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004222Metalloendopeptidase activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIEAbiological_process
GO:0030574Collagen catabolic processIEA TASbiological_process
GO:0031012Extracellular matrixIDA IEAcellular_component
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0071711Basement membrane organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52436164280.73389838150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0054769662
GSE13712_SHEARDown-0.2269356127
GSE13712_STATICDown-0.2532732943
GSE19018Up0.0874602735
GSE19899_A1Up0.0018551943
GSE19899_A2Up0.0347487074
PubMed_21979375_A1Down-0.0599520211
PubMed_21979375_A2Down-0.0633455373
GSE35957Up0.1416607042
GSE36640Up0.0716380375
GSE54402Down-0.0871467162
GSE9593Down-0.0578930370
GSE43922Up0.0352612456
GSE24585Up0.0343729579
GSE37065Up0.0622022187
GSE28863_A1Up0.1364515614
GSE28863_A2Up0.1727630370
GSE28863_A3Up0.2052497239
GSE28863_A4Up0.0672157408
GSE48662Up0.5165404538

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MarimastatDB00786 APRD00559
1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic AcidDB04318 EXPT02827

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT006905Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22768249
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.