HCSGD entry for MMP10
1. General information
| Official gene symbol | MMP10 |
|---|---|
| Entrez ID | 4319 |
| Gene full name | matrix metallopeptidase 10 (stromelysin 2) |
| Other gene symbols | SL-2 STMY2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000094107 | 0.9118643175 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.3224223461 |
| GSE13712_SHEAR | Up | 2.5932018768 |
| GSE13712_STATIC | Up | 2.0925492439 |
| GSE19018 | Up | 0.3214846731 |
| GSE19899_A1 | Up | 6.3351871280 |
| GSE19899_A2 | Up | 3.2558378109 |
| PubMed_21979375_A1 | Up | 8.4106180236 |
| PubMed_21979375_A2 | Up | 9.1817601602 |
| GSE35957 | Down | -0.2925492739 |
| GSE36640 | Up | 1.0102601235 |
| GSE54402 | Up | 5.9509132317 |
| GSE9593 | Down | -0.0030704331 |
| GSE43922 | Up | 3.9628185898 |
| GSE24585 | Down | -0.1730720781 |
| GSE37065 | Up | 1.2118012681 |
| GSE28863_A1 | Down | -0.1205560869 |
| GSE28863_A2 | Down | -0.3688685228 |
| GSE28863_A3 | Down | -0.5940708272 |
| GSE28863_A4 | Down | -0.1695807655 |
| GSE48662 | Down | -0.0394215940 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
| N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID | DB08271 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028865 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26618897 | Moreover, LiCl boosted 8-oxo-dG staining, expression of IKKalpha and MMP-10 |
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