HCSGD entry for MMP9
1. General information
| Official gene symbol | MMP9 |
|---|---|
| Entrez ID | 4318 |
| Gene full name | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
| Other gene symbols | CLG4B GELB MANDP2 MMP-9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | IEA | biological_process |
| GO:0004222 | Metalloendopeptidase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005518 | Collagen binding | TAS | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006508 | Proteolysis | IDA | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030225 | Macrophage differentiation | TAS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0051549 | Positive regulation of keratinocyte migration | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0255374682 | 0.9558878842 | 0.3748866146 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2330734329 |
| GSE13712_SHEAR | Up | 0.0816298203 |
| GSE13712_STATIC | Up | 0.0484910747 |
| GSE19018 | Up | 0.0803792610 |
| GSE19899_A1 | Up | 0.1962527790 |
| GSE19899_A2 | Up | 0.3654273335 |
| PubMed_21979375_A1 | Up | 1.7362748403 |
| PubMed_21979375_A2 | Up | 0.6604249577 |
| GSE35957 | Down | -0.2189394635 |
| GSE36640 | Up | 0.0305558500 |
| GSE54402 | Up | 2.8367257468 |
| GSE9593 | Up | 0.1414902438 |
| GSE43922 | Up | 0.0213535785 |
| GSE24585 | Up | 0.1374372429 |
| GSE37065 | Down | -0.0715458121 |
| GSE28863_A1 | Up | 0.1290868174 |
| GSE28863_A2 | Up | 0.0174584739 |
| GSE28863_A3 | Up | 0.3728549523 |
| GSE28863_A4 | Up | 0.1624982141 |
| GSE48662 | Up | 0.0377689287 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
| Minocycline | DB01017 | APRD00547 |
| Glucosamine | DB01296 | EXPT01563 |
| 2-Amino-N,3,3-Trimethylbutanamide | DB01949 | EXPT00776 |
| 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid | DB03683 | EXPT02969 |
| AE-941 | DB05387 | - |
| PG-530742 | DB05495 | - |
| 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE | DB07117 | - |
| (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE | DB07246 | - |
| (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID | DB07285 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-451a | MIMAT0001631 | MIRT005743 | qRT-PCR//Western blot | Functional MTI | 20816946 |
| hsa-miR-338-3p | MIMAT0000763 | MIRT019229 | Western blot;qRT-PCR | Functional MTI | 21671467 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030871 | qRT-PCR | Functional MTI (Weak) | 19435867 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 17 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27259496 | The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy |
| 27259496 | All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging |
| 26391655 | In vivo, defective VSMC autophagy led to upregulation of MMP9, TGFB and CXCL12 and promoted postinjury neointima formation and diet-induced atherogenesis |
| 25481090 | Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells |
| 25481090 | In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment |
| 25346044 | Although PINCH-2 expression of survival pathway-related proteins (Akt and phospho-Akt) did not change upon suppression of PINCH-2 expression, cell migration-related proteins [matrix-metalloproteinase (MMP)-9 and -11] were upregulated through autocrine and paracrine activation |
| 24917789 | In contrast, 16 DIV (aged) microglia evidenced ramified morphology and increased matrix metalloproteinase (MMP)-2 activation, as well as reduced MMP-9, glutamate release and nuclear factor kappa-B activation, in parallel with decreased expression of Toll-like receptor (TLR)-2 and TLR-4, capacity to migrate and phagocytose |
| 24475901 | In addition, mRNA levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1, and concentration of beta-galactose were all measured to confirm cell senescence |
| 24033117 | Immunohistochemistry of matrix metalloproteinase 9 (MMP9) was also performed on PFP tissue sections |
| 24033117 | The shift of the types of adipocyte clusters in the aged PFP was accompanied by degradation of elastin fibers and increased expression of MMP9 |
| 23907579 | Moreover, DHA induced cellular senescence, G1 phase cell cycle arrest and hindered the migration and invasion of gastric cancer cells corresponding with downregulation of MMP-9 and MMP-2 |
| 23719597 | In primary PSC, doxorubicin treatment was associated with increased expression of interleukin-6 (IL-6) and matrix metalloproteinase (MMP)-9, while expression of the activation marker alpha-smooth muscle actin (alpha-SMA), p53, Cdk1 and Rad54 was diminished |
| 23557734 | For inhibitory studies, MMP-9 was inhibited by RNA interference strategy |
| 23557734 | RESULTS: Abeta promotes RPE cells to enter senescence and secrete higher concentrations of IL-8 and MMP-9 |
| 23557734 | Secretion of MMP-9 is associated with compromised barrier integrity and with processing of IL-8 to a more activated form |
| 23557734 | Silence of MMP-9 preserved the barrier integrity of senescent RPE cells |
| 22516759 | Also our study indicated that WSC induced an increase in the transcriptional expression of matrix metalloproteinases, MMP-2 and MMP-9 and an immune response regulator, Toll Like Receptor-4 |
| 22362388 | Reduced matrix metalloproteinase (MMP)-2 and MMP-9 expressions indicated a low profile of senescence-associated secretory phenotype (SASP) in the bleomycin-injured cav-1(-/-) mice |
| 20836084 | MMP-2 and MMP-9 immunostaining also showed an increased reaction in the muscle fiber cytoplasm and endomisium during SAHS progression |
| 20407016 | Vascular endothelial cells produce considerable amounts of matrix metalloproteinases (MMP), including MMP-2, MMP-9, and membrane type 1 (MT1)-MMP |
| 20139322 | Further studies revealed that the upregulation of matrix metalloproteinase-9 is the underlying mechanisms of disruption of tight junction proteins in hCMEC/D3 cells with inhibited TERT and exposed to HIV-1 |
| 18314458 | Plaques were analyzed for ubiquitin levels, proteasome 20S activity, p16 and p53, nitrotyrosine, matrix metalloproteinase-9 (MMP-9) and collagen content (immunohistochemistry and enzyme-linked immunosorbent assay) |
| 13679081 | In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells |
| 13679081 | Matrix metalloproteinase-9 (MMP-9) expression was also increased in response to tumor necrosis factor-alpha (TNF-alpha) in aged MASMC, as evidenced by zymography and immunoblot analysis |
| 13679081 | Transient transfection assays showed an age-dependent increase in transcription from MMP-9 promoter activity in response to TNF-alpha |
| 13679081 | These results suggest that the age-associated increase in SMC proliferative capacity, accumulative cell cycle regulators, and MMP-9 expression may play a role in vascular remodeling during in vitro aging |
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