HCSGD entry for MMP8

1. General information

Official gene symbolMMP8
Entrez ID4317
Gene full namematrix metallopeptidase 8 (neutrophil collagenase)
Other gene symbolsCLG1 HNC MMP-8 PMNL-CL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004222Metalloendopeptidase activityIEAmolecular_function
GO:0004252Serine-type endopeptidase activityIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0008270Zinc ion bindingIEA TASmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0031012Extracellular matrixIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06713332320.63757469700.55794638461.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1119125961
GSE13712_SHEARUp0.0037919367
GSE13712_STATICUp0.0079092759
GSE19018Up0.1437467928
GSE19899_A1Up0.0355058221
GSE19899_A2Up0.5901598026
PubMed_21979375_A1Up0.3591701377
PubMed_21979375_A2Up0.3277543912
GSE35957Up0.0807965560
GSE36640Up0.0207566051
GSE54402Up2.2184593753
GSE9593Up0.0100672529
GSE43922Up0.8951595857
GSE24585Down-0.2046371644
GSE37065Down-0.4794901888
GSE28863_A1Down-0.2629604371
GSE28863_A2Down-0.0354329951
GSE28863_A3Down-0.0408722669
GSE28863_A4Down-0.2152717065
GSE48662Up0.0542649452

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MarimastatDB00786 APRD00559
1-Hydroxyamine-2-Isobutylmalonic AcidDB02326 EXPT01761 | DB07904
2-Thiomethyl-3-Phenylpropanoic AcidDB02953 EXPT00769
2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic AcidDB03207 EXPT00763
2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-DioneDB03622 EXPT00635
GlycinamidDB03636 EXPT01617
BatimastatDB03880 EXPT00627
N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREADB06971 -
(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamideDB07397 -
(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACIDDB07713 -
(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACIDDB07772 -
3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDEDB07900 -
BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINEDB08028 -
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACIDDB08403 -
3-AMINO-AZACYCLOTRIDECAN-2-ONEDB08476 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028875MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.