HCSGD entry for MMP7
1. General information
| Official gene symbol | MMP7 |
|---|---|
| Entrez ID | 4316 |
| Gene full name | matrix metallopeptidase 7 (matrilysin, uterine) |
| Other gene symbols | MMP-7 MPSL1 PUMP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002779 | Antibacterial peptide secretion | IEA | biological_process |
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0050829 | Defense response to Gram-negative bacterium | IEA | biological_process |
| GO:0050830 | Defense response to Gram-positive bacterium | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1258823867 | 0.7814581703 | 0.7235969207 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1642792739 |
| GSE13712_SHEAR | Up | 0.1019985788 |
| GSE13712_STATIC | Down | -0.0121651917 |
| GSE19018 | Up | 0.1340528429 |
| GSE19899_A1 | Up | 0.3645544499 |
| GSE19899_A2 | Up | 1.0116169742 |
| PubMed_21979375_A1 | Up | 0.3808491840 |
| PubMed_21979375_A2 | Up | 0.2910433168 |
| GSE35957 | Down | -0.0145588522 |
| GSE36640 | Up | 0.0312728301 |
| GSE54402 | Up | 0.0420599777 |
| GSE9593 | Up | 0.1233388619 |
| GSE43922 | Up | 0.3248488820 |
| GSE24585 | Up | 0.0428271808 |
| GSE37065 | Up | 0.6086396749 |
| GSE28863_A1 | Down | -0.3332388736 |
| GSE28863_A2 | Down | -0.4853503260 |
| GSE28863_A3 | Up | 0.1533035287 |
| GSE28863_A4 | Up | 0.0342676737 |
| GSE48662 | Down | -0.0124937822 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
| (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE | DB08170 | - |
| N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE | DB08489 | - |
| 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID | DB08493 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-5p | MIMAT0000444 | MIRT007268 | Luciferase reporter assay | Functional MTI | 23437250 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT007269 | Luciferase reporter assay | Functional MTI | 23437250 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21507328 | Besides the contribution of reactive oxygen species and telomere dysfunction to aging, it is the aim of this mini-review, to compare distinct changes to extracellular signals by certain matrix metalloproteinases including MMP-7 and associated growth factor pathways mediated by HB-EGF activation in young and aging HMEC |
| 19682489 | Cellular senescence of human mammary epithelial cells (HMEC) is associated with an altered MMP-7/HB-EGF signaling and increased formation of elastin-like structures |
| 19682489 | RNAi experiments revealed both the ECM metalloproteinase MMP-7 and the growth factor HB-EGF as potential effectors of an increased tropoelastin expression |
| 19682489 | Moreover, co-localization of MMP-7 and HB-EGF as well as a concomittant downstream signaling via Fra-1 indicated a possible association between the reduced MMP-7 enzyme activity and an impaired HB-EGF processing, resulting in an enhanced tropoelastin synthesis during senescence of HMEC |
| 19682489 | In agreement with previous work, these findings suggested an important influence of the extracellular proteinase MMP-7 on the aging process of HMEC, affecting both extracellular remodeling as well as intracellular signaling pathways |
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