HCSGD entry for NR3C2
1. General information
| Official gene symbol | NR3C2 |
|---|---|
| Entrez ID | 4306 |
| Gene full name | nuclear receptor subfamily 3, group C, member 2 |
| Other gene symbols | MCR MLR MR NR3C2VIT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006883 | Cellular sodium ion homeostasis | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007588 | Excretion | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0279368185 | 0.1370992667 | 0.3872366316 | 0.7133010081 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3179464080 |
| GSE13712_SHEAR | Down | -0.1349049089 |
| GSE13712_STATIC | Up | 0.2178638463 |
| GSE19018 | Down | -0.6223138224 |
| GSE19899_A1 | Down | -0.0194653407 |
| GSE19899_A2 | Up | 2.9088181188 |
| PubMed_21979375_A1 | Down | -1.2542261393 |
| PubMed_21979375_A2 | Up | 0.5443658292 |
| GSE35957 | Up | 3.8983389995 |
| GSE36640 | Up | 2.0176439926 |
| GSE54402 | Down | -0.4189076238 |
| GSE9593 | Down | -0.1370124334 |
| GSE43922 | Down | -0.8183110338 |
| GSE24585 | Up | 0.2709228913 |
| GSE37065 | Down | -0.0750614808 |
| GSE28863_A1 | Down | -0.2967578408 |
| GSE28863_A2 | Down | -0.0007495792 |
| GSE28863_A3 | Up | 0.0834412873 |
| GSE28863_A4 | Down | -0.0322605348 |
| GSE48662 | Up | 0.3649183763 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Spironolactone | DB00421 | APRD01234 |
| Fluticasone Propionate | DB00588 | APRD00065 |
| Fludrocortisone | DB00687 | APRD00756 | DB02478 |
| Eplerenone | DB00700 | APRD00707 |
| Drospirenone | DB01395 | - |
| (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE | DB04652 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-19b-3p | MIMAT0000074 | MIRT001164 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-135a-5p | MIMAT0000428 | MIRT001167 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19944075 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT001168 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19944075 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017785 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019372 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27158328 | Mineralocorticoid receptor is involved in the aldosterone pathway in human red blood cells |
| 27158328 | These alterations were prevented/inhibited by cortisol (Cort) or canrenone (Can) raising the hypothesis that Aldo effects in RBC may be mediated by mineralocorticoid receptor (MR), though to date MR has never been demonstrated in human RBC |
| 26260874 | METHODS: Analyses included Munich Cancer Registry (MCR) data from 8601 invasive gastric cancer patients, diagnosed between 1998 and 2012 |
| 26260874 | CONCLUSION: The treatment and care of elderly gastric cancer patients in the MCR catchment area seems appropriate: if a patient's general condition allows oncologic resection and chemotherapy, it is conducted and the result is comparable between age groups |
| 21190955 | These changes were abolished by eplerenone (100 mg/kg/d), a mineralocorticoid receptor (MR) antagonist, but unaffected by hydralazine (80 mg/liter in drinking water) |
| 18410543 | No expression of the mineralocorticoid receptor (MR) transcript was found in EPC by RT-PCR analysis |
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