HCSGD entry for FOXO4

1. General information

Official gene symbolFOXO4
Entrez ID4303
Gene full nameforkhead box O4
Other gene symbolsAFX AFX1 MLLT7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0007095Mitotic G2 DNA damage checkpointIBAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008286Insulin receptor signaling pathwayIDAbiological_process
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0009888Tissue developmentIBAbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0032873Negative regulation of stress-activated MAPK cascadeIBAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043066Negative regulation of apoptotic processIBAbiological_process
GO:0043565Sequence-specific DNA bindingIMPmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048863Stem cell differentiationIMPbiological_process
GO:0051151Negative regulation of smooth muscle cell differentiationIDAbiological_process
GO:0070317Negative regulation of G0 to G1 transitionIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12778177500.83096466320.72726817891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1597518189
GSE13712_SHEARDown-0.2146344784
GSE13712_STATICDown-0.2353247145
GSE19018Up0.5839690001
GSE19899_A1Down-0.1623807608
GSE19899_A2Up0.4874712206
PubMed_21979375_A1Down-0.0508705749
PubMed_21979375_A2Down-0.0620812859
GSE35957Up0.2202482631
GSE36640Up0.9077106779
GSE54402Down-0.2250340517
GSE9593Up0.2362123956
GSE43922Up0.0560404412
GSE24585Up0.4463403394
GSE37065Down-0.0243332495
GSE28863_A1Down-0.1166900176
GSE28863_A2Up0.3172378321
GSE28863_A3Up0.2385221297
GSE28863_A4Down-0.0049550034
GSE48662Up0.1940119482

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-499b-5pMIMAT0019897MIRT006698Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21934092
hsa-miR-335-5pMIMAT0000765MIRT018590MicroarrayFunctional MTI (Weak)18185580
hsa-miR-615-3pMIMAT0003283MIRT039705CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26833729We uncovered multiple genes known to be involved in p53 and Rb regulation and ATM regulation, two components of the CST (CTC1-STN1-TEN1) complex involved in preventing telomere erosion, and genes such as REST and FOXO4 that have been implicated in aging
24984152METHODS AND RESULTS: Treatment of human EPCs with HKa for 72h stimulated JNK phosphorylation at Thr183/Tyr185, and FOXO4 phosphorylation at Thr451, Concomitantly, upregulated the expression of MnSOD at protein and mRNA levels in a concentration-dependent manner
24984152Moreover, HC at 50 nM increased FOXO4 phosphorylation at Thr451 and the protein level of MnSOD in EPCs
24269635RESULTS: Human cartilage expressed FOXO1 and FOXO3 but not FOXO4 proteins
20959475BRAF(V600E) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-Jun NH(2) terminal kinase-mediated activation of FOXO4 via its phosphorylation on Thr(223), Ser(226), Thr(447), and Thr(451)
20959475BRAF(V600E)-induced FOXO4 phosphorylation resulted in p21(cip1)-mediated cell senescence independent of p16(ink4a) or p27(kip1)
20959475Importantly, melanocyte-specific activation of BRAF(V600E) in vivo resulted in the formation of skin nevi expressing Thr(223)/Ser(226)-phosphorylated FOXO4 and elevated p21(cip1)
15741276The FOXO family of forkhead transcription factors, FOXO1, FOXO3a, and FOXO4, play a critical role in this signal transduction pathway
Entries Per Page
Displaying Page of