HCSGD entry for KMT2A

1. General information

Official gene symbolKMT2A
Entrez ID4297
Gene full namelysine (K)-specific methyltransferase 2A
Other gene symbolsALL-1 CXXC7 HRX HTRX1 MLL MLL/GAS7 MLL1A TET1-MLL TRX1 WDSTS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0003680AT DNA bindingNASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0006306DNA methylationIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006461Protein complex assemblyIDAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0008270Zinc ion bindingIDA IEAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0032411Positive regulation of transporter activityIMPbiological_process
GO:0035097Histone methyltransferase complexIDAcellular_component
GO:0035162Embryonic hemopoiesisTASbiological_process
GO:0042800Histone methyltransferase activity (H3-K4 specific)IDA IMPmolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043984Histone H4-K16 acetylationIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045322Unmethylated CpG bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0051568Histone H3-K4 methylationIDA IMPbiological_process
GO:0051569Regulation of histone H3-K4 methylationIEAbiological_process
GO:0070577Histone acetyl-lysine bindingIDAmolecular_function
GO:0071339MLL1 complexIDAcellular_component
GO:0080182Histone H3-K4 trimethylationIDAbiological_process
GO:2001040Positive regulation of cellular response to drugIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08433977810.97842457350.61040299621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0432207930
GSE13712_SHEARUp0.2427649520
GSE13712_STATICUp0.2003927140
GSE19018Up0.2987675897
GSE19899_A1Up0.0500238953
GSE19899_A2Up0.0424708712
PubMed_21979375_A1Up0.2120503904
PubMed_21979375_A2Up0.0998447616
GSE35957Down-0.0468743765
GSE36640Down-0.1613544274
GSE54402Up0.1304182153
GSE9593Up0.0733751457
GSE43922Up0.0131056264
GSE24585Down-0.0630603299
GSE37065Up0.1300692572
GSE28863_A1Up0.7154553051
GSE28863_A2Up0.6664131656
GSE28863_A3Up0.3403020188
GSE28863_A4Up0.0644185239
GSE48662Up0.1319270808

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017178MicroarrayFunctional MTI (Weak)18185580
hsa-miR-16-5pMIMAT0000069MIRT031581SequencingFunctional MTI (Weak)20371350
hsa-let-7d-5pMIMAT0000065MIRT032120SequencingFunctional MTI (Weak)20371350
hsa-miR-320bMIMAT0005792MIRT036224CLASHFunctional MTI (Weak)23622248
hsa-miR-1227-3pMIMAT0005580MIRT036400CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042344CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044681CLASHFunctional MTI (Weak)23622248
hsa-miR-193a-3pMIMAT0000459MIRT044880CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051043CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25675863We found a significantly increased expression of p16(INK4A) in BCP-ALLs with MLL rearrangement
21624810Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells
21624810Together, these results reveal an important functional interplay between MLL/Hox and Bmi1 in regulating cellular senescence for LSC development, suggesting that a synergistic targeting of both molecules is required to eradicate a broader spectrum of LSCs
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