HCSGD entry for MAP3K11

1. General information

Official gene symbolMAP3K11
Entrez ID4296
Gene full namemitogen-activated protein kinase kinase kinase 11
Other gene symbolsMEKK11 MLK-3 MLK3 PTK1 SPRK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000080Mitotic G1 phaseIMPbiological_process
GO:0000187Activation of MAPK activityIMPbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004706JUN kinase kinase kinase activityIEA ISSmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007017Microtubule-based processIMPbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007257Activation of JUN kinase activityIMPbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008283Cell proliferationIMPbiological_process
GO:0031434Mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIPImolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043507Positive regulation of JUN kinase activityIMPbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046777Protein autophosphorylationIDA IEAbiological_process
GO:0048365Rac GTPase bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16819443030.72171446750.80904208701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0535767594
GSE13712_SHEARUp0.0568165474
GSE13712_STATICDown-0.1038152303
GSE19018Up0.1021441300
GSE19899_A1Up0.1907354607
GSE19899_A2Up0.6257077234
PubMed_21979375_A1Up0.3997487804
PubMed_21979375_A2Up1.4406268836
GSE35957Down-0.2754241431
GSE36640Up0.0192711521
GSE54402Up0.2761713411
GSE9593Down-0.0954326051
GSE43922Up0.2693549357
GSE24585Up0.0341055061
GSE37065Up0.1430455647
GSE28863_A1Down-0.1246750066
GSE28863_A2Down-0.2027516772
GSE28863_A3Down-0.4200983002
GSE28863_A4Up0.0170454739
GSE48662Down-0.3151557367

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199a-5pMIMAT0000231MIRT005873Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21048306
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.