HCSGD entry for MLH1
1. General information
| Official gene symbol | MLH1 |
|---|---|
| Entrez ID | 4292 |
| Gene full name | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
| Other gene symbols | COCA2 FCC2 HNPCC HNPCC2 hMLH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | IEA | biological_process |
| GO:0000712 | Resolution of meiotic recombination intermediates | IEA | biological_process |
| GO:0000795 | Synaptonemal complex | IBA IEA | cellular_component |
| GO:0001673 | Male germ cell nucleus | IEA | cellular_component |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IC IEA | cellular_component |
| GO:0005712 | Chiasma | IBA IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IBA | biological_process |
| GO:0006298 | Mismatch repair | IBA IEA IGI | biological_process |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IEA | biological_process |
| GO:0007060 | Male meiosis chromosome segregation | IEA | biological_process |
| GO:0007129 | Synapsis | IEA | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | IBA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
| GO:0016446 | Somatic hypermutation of immunoglobulin genes | IBA IEA | biological_process |
| GO:0016887 | ATPase activity | IBA | molecular_function |
| GO:0030983 | Mismatched DNA binding | IEA | molecular_function |
| GO:0032137 | Guanine/thymine mispair binding | IEA | molecular_function |
| GO:0032300 | Mismatch repair complex | IBA | cellular_component |
| GO:0032389 | MutLalpha complex | IBA IEA | cellular_component |
| GO:0032390 | MutLbeta complex | IBA | cellular_component |
| GO:0032407 | MutSalpha complex binding | IDA | molecular_function |
| GO:0043060 | Meiotic metaphase I plate congression | IEA | biological_process |
| GO:0045190 | Isotype switching | IEA | biological_process |
| GO:0045950 | Negative regulation of mitotic recombination | IEA | biological_process |
| GO:0048477 | Oogenesis | IEA | biological_process |
| GO:0051257 | Spindle midzone assembly involved in meiosis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9918339197 | 0.0085648646 | 0.9999902473 | 0.1849068627 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1327330555 |
| GSE13712_SHEAR | Up | 0.0743487053 |
| GSE13712_STATIC | Down | -0.0978992132 |
| GSE19018 | Down | -0.3224460125 |
| GSE19899_A1 | Down | -1.5262274232 |
| GSE19899_A2 | Down | -0.8316097759 |
| PubMed_21979375_A1 | Down | -0.6145906010 |
| PubMed_21979375_A2 | Down | -0.9360882618 |
| GSE35957 | Down | -0.2780434145 |
| GSE36640 | Down | -0.5903322241 |
| GSE54402 | Down | -0.3179105706 |
| GSE9593 | Down | -0.3423682060 |
| GSE43922 | Down | -0.5734895458 |
| GSE24585 | Up | 0.1239211851 |
| GSE37065 | Up | 0.0111494379 |
| GSE28863_A1 | Down | -0.0417412304 |
| GSE28863_A2 | Down | -0.0028518315 |
| GSE28863_A3 | Down | -0.6942492889 |
| GSE28863_A4 | Down | -0.1963049171 |
| GSE48662 | Down | -0.2288541666 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT000461 | Luciferase reporter assay//Western blot//Northern blot | Functional MTI | 20351277 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028566 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT035519 | Luciferase reporter assay | Functional MTI | 23539435 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
