HCSGD entry for MLF1
1. General information
| Official gene symbol | MLF1 |
|---|---|
| Entrez ID | 4291 |
| Gene full name | myeloid leukemia factor 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002318 | Myeloid progenitor cell differentiation | ISS | biological_process |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | ISS | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0019904 | Protein domain specific binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9944755670 | 0.0059488355 | 0.9999902473 | 0.1558002985 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6200502959 |
| GSE13712_SHEAR | Down | -0.4939015440 |
| GSE13712_STATIC | Down | -0.9176964613 |
| GSE19018 | Down | -0.4084240440 |
| GSE19899_A1 | Down | -0.1442270727 |
| GSE19899_A2 | Down | -1.4235276815 |
| PubMed_21979375_A1 | Down | -0.1726807019 |
| PubMed_21979375_A2 | Down | -0.4660062180 |
| GSE35957 | Down | -0.3769944980 |
| GSE36640 | Down | -0.0454451338 |
| GSE54402 | Down | -0.6996759864 |
| GSE9593 | Down | -0.1517031694 |
| GSE43922 | Down | -0.0603907659 |
| GSE24585 | Up | 0.4792548509 |
| GSE37065 | Down | -0.0704606696 |
| GSE28863_A1 | Down | -0.2370145264 |
| GSE28863_A2 | Up | 0.0655019845 |
| GSE28863_A3 | Down | -0.2334281585 |
| GSE28863_A4 | Down | -0.2177729993 |
| GSE48662 | Down | -0.4014986072 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-422a | MIMAT0001339 | MIRT042653 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043951 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17967869 | Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation |
| 17967869 | However, little is known about how MLF1 functions upstream of the CSN3-COP1-p53 pathway and how its deregulation by the formation of the fusion protein nucleophosmin (NPM)-MLF1, generated by t(3;5)(q25 |
| 17967869 | Here we show that MLF1 is a cytoplasmic-nuclear-shuttling protein and that its nucleolar localization on fusing with NPM prevents the full induction of p53 by both genotoxic and oncogenic cellular stress |
| 17967869 | The majority of MLF1 was located in the cytoplasm, but the treatment of cells with leptomycin B rapidly induced a nuclear accumulation of MLF1 |
| 17967869 | A mutation of the nuclear export signal (NES) motif identified in the MLF1 sequence enhanced the antiproliferative activity of MLF1 |
| 17967869 | The fusion of MLF1 with NPM translocated MLF1 to the nucleolus and abolished the growth-suppressing activity |
| 17967869 | Thus, our results provide important evidence that the shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation |
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