HCSGD entry for CXCL9
1. General information
| Official gene symbol | CXCL9 |
|---|---|
| Entrez ID | 4283 |
| Gene full name | chemokine (C-X-C motif) ligand 9 |
| Other gene symbols | CMK Humig MIG SCYB9 crg-10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | IDA | biological_process |
| GO:0006952 | Defense response | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0006968 | Cellular defense response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008009 | Chemokine activity | IDA | molecular_function |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0030816 | Positive regulation of cAMP metabolic process | IDA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IDA | biological_process |
| GO:0043950 | Positive regulation of cAMP-mediated signaling | IDA | biological_process |
| GO:0048248 | CXCR3 chemokine receptor binding | IDA | molecular_function |
| GO:0051281 | Positive regulation of release of sequestered calcium ion into cytosol | IDA | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
| GO:0060326 | Cell chemotaxis | IDA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6231450743 | 0.6458836214 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2052153081 |
| GSE13712_SHEAR | Up | 0.2093302320 |
| GSE13712_STATIC | Up | 0.3897839433 |
| GSE19018 | Down | -0.0497627491 |
| GSE19899_A1 | Up | 0.1103998027 |
| GSE19899_A2 | Down | -0.0744653559 |
| PubMed_21979375_A1 | Up | 0.1498582541 |
| PubMed_21979375_A2 | Down | -0.0136528758 |
| GSE35957 | Up | 0.1655813689 |
| GSE36640 | Up | 0.1709927903 |
| GSE54402 | Up | 0.0834610211 |
| GSE9593 | Up | 0.0068995100 |
| GSE43922 | Up | 0.0136340383 |
| GSE24585 | Up | 0.0323806627 |
| GSE37065 | Down | -0.0318809790 |
| GSE28863_A1 | Down | -0.1438733893 |
| GSE28863_A2 | Down | -0.1869479426 |
| GSE28863_A3 | Down | -0.0115419821 |
| GSE28863_A4 | Up | 0.0030810125 |
| GSE48662 | Up | 0.0590611567 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016944 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025283 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028888 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25540416 | EBNA3A was at MYC, CDKN2A/B, CCND2, CXCL9/10, and BCL2, together with RUNX3, BATF, IRF4, and SPI1 |
| 25398437 | In the model studied, this effect is accompanied by proliferation arrest, mitochondrial depolarization, apoptosis, and immune clearance of cancer cells by antitumor leukocytes in a manner reliant upon Ccl5, Ccl1, and Cxcl9 |
| 24499954 | Changes were related to proportions of CD4 T cells expressing HLA-DR or CD57 and plasma levels of sCD14, CXCL9 and CXCL10 |
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