HCSGD entry for MIF
1. General information
| Official gene symbol | MIF |
|---|---|
| Entrez ID | 4282 |
| Gene full name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
| Other gene symbols | GIF GLIF MMIF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001516 | Prostaglandin biosynthetic process | IDA | biological_process |
| GO:0002906 | Negative regulation of mature B cell apoptotic process | IEA | biological_process |
| GO:0004167 | Dopachrome isomerase activity | IDA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005125 | Cytokine activity | IDA | molecular_function |
| GO:0005126 | Cytokine receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IDA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | IDA | biological_process |
| GO:0007569 | Cell aging | IEA | biological_process |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010629 | Negative regulation of gene expression | IDA | biological_process |
| GO:0010739 | Positive regulation of protein kinase A signaling | IDA | biological_process |
| GO:0019752 | Carboxylic acid metabolic process | IDA | biological_process |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | IEA | biological_process |
| GO:0030890 | Positive regulation of B cell proliferation | IDA | biological_process |
| GO:0031666 | Positive regulation of lipopolysaccharide-mediated signaling pathway | IEA | biological_process |
| GO:0032269 | Negative regulation of cellular protein metabolic process | IEA | biological_process |
| GO:0033033 | Negative regulation of myeloid cell apoptotic process | IEA | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0042056 | Chemoattractant activity | IDA | molecular_function |
| GO:0042327 | Positive regulation of phosphorylation | IDA | biological_process |
| GO:0043030 | Regulation of macrophage activation | NAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043406 | Positive regulation of MAP kinase activity | IEA | biological_process |
| GO:0043518 | Negative regulation of DNA damage response, signal transduction by p53 class mediator | IDA | biological_process |
| GO:0045087 | Innate immune response | IEA | biological_process |
| GO:0048146 | Positive regulation of fibroblast proliferation | IDA | biological_process |
| GO:0050178 | Phenylpyruvate tautomerase activity | IDA | molecular_function |
| GO:0050715 | Positive regulation of cytokine secretion | IDA | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0050918 | Positive chemotaxis | IDA | biological_process |
| GO:0061078 | Positive regulation of prostaglandin secretion involved in immune response | IEA | biological_process |
| GO:0061081 | Positive regulation of myeloid leukocyte cytokine production involved in immune response | IEA | biological_process |
| GO:0070207 | Protein homotrimerization | IPI | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IDA | biological_process |
| GO:0071157 | Negative regulation of cell cycle arrest | IDA | biological_process |
| GO:0090238 | Positive regulation of arachidonic acid secretion | IEA | biological_process |
| GO:0090344 | Negative regulation of cell aging | IDA | biological_process |
| GO:1902166 | Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA | biological_process |
| GO:2000343 | Positive regulation of chemokine (C-X-C motif) ligand 2 production | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0784569203 | 0.5090504046 | 0.5908625465 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1030838830 |
| GSE13712_SHEAR | Up | 0.2580197078 |
| GSE13712_STATIC | Down | -0.0059635268 |
| GSE19018 | Up | 1.1833514235 |
| GSE19899_A1 | Up | 0.1396810231 |
| GSE19899_A2 | Up | 0.1792033169 |
| PubMed_21979375_A1 | Up | 2.3873386607 |
| PubMed_21979375_A2 | Up | 0.1790371589 |
| GSE35957 | Down | -0.7739471709 |
| GSE36640 | Down | -1.5277258159 |
| GSE54402 | Up | 0.2871785089 |
| GSE9593 | Up | 0.1484485845 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.5080169980 |
| GSE28863_A2 | Up | 0.1722927926 |
| GSE28863_A3 | Up | 0.2944852007 |
| GSE28863_A4 | Down | -0.0800713205 |
| GSE48662 | Up | 0.1823283975 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 3,4-Dihydroxycinnamic Acid | DB01880 | EXPT01188 |
| 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester | DB02728 | EXPT03279 |
| Citric Acid | DB04272 | EXPT00922 |
| 3-(4-HYDROXY-PHENYL)PYRUVIC ACID | DB07718 | - |
| 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER | DB07888 | - |
| 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME | DB08333 | - |
| 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME | DB08334 | - |
| 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME | DB08335 | - |
| 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE | DB08765 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-451a | MIMAT0001631 | MIRT000046 | ELISA//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 19318487 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037678 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039145 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044670 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26160351 | Recent reports that migration inhibitory factor (MIF) or periodic fasting rejuvenate old MSCs provide the opportunity to link intrinsic and extrinsic mechanisms of aging in novel and potentially medically important ways and may lead to anti-aging treatments that reorganize the epigenome to rejuvenate cells and tissues |
| 24441872 | Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease |
| 24441872 | MIF plasma concentrations were measured in a cohort of 224 human participants |
| 24274936 | Macrophage migration inhibitory factor regulates AKT signaling in hypoxic culture to modulate senescence of human mesenchymal stem cells |
| 24274936 | The hypoxic condition also delayed cellular senescence of hMSCs, increased activation of AKT signaling, and upregulated both intra- and extracellular levels of macrophage migration inhibitory factor (MIF) compared to the normoxic condition |
| 24274936 | The hypoxic condition also delayed cellular senescence of hMSCs, increased activation of AKT signaling, and upregulated both intra- and extracellular levels of macrophage migration inhibitory factor (MIF) compared to the normoxic condition |
| 24274936 | On the other hand, upregulated intra- and extracellular levels of MIF by stable MIF overexpression in normoxic culture increased the activation of AKT while decreasing mRNA expression of senescence-associated markers and increasing expression of potency-associated markers |
| 24274936 | On the other hand, upregulated intra- and extracellular levels of MIF by stable MIF overexpression in normoxic culture increased the activation of AKT while decreasing mRNA expression of senescence-associated markers and increasing expression of potency-associated markers |
| 24274936 | Taken together, our findings suggest that hMSCs in hypoxic culture produce endogenous MIF to activate AKT signaling to delay the progression of cellular senescence |
| 20940041 | Control of p53 and NF-kappaB signaling by WIP1 and MIF: role in cellular senescence and organismal aging |
| 20940041 | WIP1 (wildtype p53-induced phosphatase 1) and MIF (macrophage migration inhibitory factor) are signaling molecules which link together the p53 and NF-kappaB pathways via positive and negative feedback loops |
| 20940041 | WIP1 (wildtype p53-induced phosphatase 1) and MIF (macrophage migration inhibitory factor) are signaling molecules which link together the p53 and NF-kappaB pathways via positive and negative feedback loops |
| 20940041 | MIF is a pro-inflammatory cytokine which inhibits the function of p53 signaling whereas it is linked to NF-kappaB signaling via a positive feedback loop |
| 20940041 | MIF knockout mice are healthier and live longer than their wild-type counterparts |
| 20940041 | An increased level of MIF can support inflammatory responses via enhancing NF-kappaB signaling and repressing the function of p53 |
| 20940041 | We will review the findings linking WIP1 and MIF to specific signaling responses of p53 and NF-kappaB and discuss their role in the regulation of cellular senescence and organismal aging |
| 17998063 | Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptation |
| 17998063 | Increasingly clear is an important regulatory role for hypoxia-inducible factor 1alpha (HIF-1alpha) in the expression of the cytokine/growth factor macrophage migration inhibitory factor (MIF) |
| 17998063 | Increasingly clear is an important regulatory role for hypoxia-inducible factor 1alpha (HIF-1alpha) in the expression of the cytokine/growth factor macrophage migration inhibitory factor (MIF) |
| 17998063 | The functional significance of hypoxia-induced MIF expression is revealed by findings demonstrating that HIF-1alpha-dependent MIF expression is necessary for hypoxia-induced evasion from cell senescence and that MIF is necessary for HIF-1alpha stabilization induced by hypoxia and prolyl hydroxylase (PHD) inhibitors |
| 17998063 | The functional significance of hypoxia-induced MIF expression is revealed by findings demonstrating that HIF-1alpha-dependent MIF expression is necessary for hypoxia-induced evasion from cell senescence and that MIF is necessary for HIF-1alpha stabilization induced by hypoxia and prolyl hydroxylase (PHD) inhibitors |
| 17998063 | The functional significance of hypoxia-induced MIF expression is revealed by findings demonstrating that HIF-1alpha-dependent MIF expression is necessary for hypoxia-induced evasion from cell senescence and that MIF is necessary for HIF-1alpha stabilization induced by hypoxia and prolyl hydroxylase (PHD) inhibitors |
| 17998063 | As the importance of MIF in hypoxic adaptation of human tumors is now becoming fully realized, we review protocols designed to evaluate MIF expression, activity, and functional consequences in hypoxic environments |
| 17998063 | As the importance of MIF in hypoxic adaptation of human tumors is now becoming fully realized, we review protocols designed to evaluate MIF expression, activity, and functional consequences in hypoxic environments |
| 17142669 | HIF1alpha delays premature senescence through the activation of MIF |
| 17142669 | Furthermore, we identify the macrophage migration inhibitory factor (MIF) as a crucial effector of HIF1alpha that delays senescence |
| 17142669 | Furthermore, we identify the macrophage migration inhibitory factor (MIF) as a crucial effector of HIF1alpha that delays senescence |
| 17142669 | Inhibition of MIF phenocopies loss of HIF1alpha |
| 17142669 | Our findings highlight a novel role for HIF1alpha under aerobic conditions, and identify MIF as a target responsible for this function |
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