HCSGD entry for KITLG

1. General information

Official gene symbolKITLG
Entrez ID4254
Gene full nameKIT ligand
Other gene symbolsFPH2 KL-1 Kitl MGF SCF SF SHEP7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001755Neural crest cell migrationIEAbiological_process
GO:0002763Positive regulation of myeloid leukocyte differentiationIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005173Stem cell factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIEA NAS TAScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008584Male gonad developmentIEPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0033026Negative regulation of mast cell apoptotic processIEAbiological_process
GO:0035162Embryonic hemopoiesisIDAbiological_process
GO:0035234Ectopic germ cell programmed cell deathIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043406Positive regulation of MAP kinase activityIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045636Positive regulation of melanocyte differentiationIEAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0046579Positive regulation of Ras protein signal transductionIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0070668Positive regulation of mast cell proliferationIEAbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02171428520.22552203180.35493269230.9134670103

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7514037220
GSE13712_SHEARUp2.0318557022
GSE13712_STATICUp0.5751243563
GSE19018Down-0.6192417153
GSE19899_A1Down-0.0614343946
GSE19899_A2Up0.5213819373
PubMed_21979375_A1Up1.1039479024
PubMed_21979375_A2Up0.5293685071
GSE35957Down-0.7080854050
GSE36640Down-1.1531747024
GSE54402Down-0.5387510803
GSE9593Up0.5788898903
GSE43922Up0.5466947165
GSE24585Down-0.4174046671
GSE37065Up0.2239364642
GSE28863_A1Up0.0641788210
GSE28863_A2Up0.0230104002
GSE28863_A3Down-0.2210051079
GSE28863_A4Up0.0858104371
GSE48662Down-0.1656434747

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-185-5pMIMAT0000455MIRT045352CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046574CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24077600S-phase kinase-associated protein 2 (Skp2) is an F box protein that plays critical roles in cell-cycle progression, senescence, metabolism, and acts as an Skp1-Cullin-1-F box (SCF) ubiquitin ligase substrate recognition factor
23911321Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
23911321This Skp2 inhibitor selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes
23278893Further evidences of AzA anti-senescence effect were repression of p53 and p21, increase in type I pro-collagen and abrogation of the enhanced expression of growth factors, such as HGF and SCF
20852063Among the cytokine combinations tested for the CD34(+) fraction, a combination (SFIb) consisting of stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand, interleukin-3, and basic fibroblast growth factor resulted in a reproducible 64- to 1468-fold EPC expansion from various cord blood origins
2085206368-fold) compared to another cytokine combination (SCF, thrombopoietin, and granulocyte colony-stimulating factor), although the two cytokine combinations had a similar level of total mononucleated cell expansion ( approximately 10% difference)
20516500We show that MUS-10 interacts with a core component of the Skp, Cullin, F-box containing (SCF) complex, SCON-3, and that its F-box domain is essential for its function in vivo
19572808However, FA MSCs showed reduced long-term proliferation ability, higher stem cell factor and interleukin-6 levels, and increased expression of senescent-associated beta-galactosidase compared to normal MSCs, suggesting a potential role of the BM microenvironment in long-term BMF
18206730CD34+ cells were expanded for 3 weeks with stem cell factor, Flt-3/Flk-2 ligand, thrombopoietin, and interleukin-6
17145814Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract
163571373 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex
16280018RESULTS: There was no correlation between age and hepatocyte growth factor (HGF), stem cell factor (SCF), and basic fibroblast growth factor (bFGF) secretion by fibroblasts
15880640Late MSCs also exhibited attenuated synthesis of the hematopoietic cytokines granulocyte colony-stimulating factor (G-CSF), leukemia inhibitory factor (LIF), and stem cell factor (SCF)
12759390RESULTS: Both melanocyte cultures showed high rates of apoptosis, which were reduced when the cells were grown in the presence of keratinocyte feeder cells or human stem cell factor plus endothelin 1
11738146Whereas, the Skp1 component of the SCF complex is overexpressed in senescent fibroblasts, the abundance of the F-box protein Skp2 is strongly reduced
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