HCSGD entry for MFGE8
1. General information
| Official gene symbol | MFGE8 |
|---|---|
| Entrez ID | 4240 |
| Gene full name | milk fat globule-EGF factor 8 protein |
| Other gene symbols | BA46 EDIL1 HMFG HsT19888 MFG-E8 MFGM OAcGD3S SED1 SPAG10 hP47 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001786 | Phosphatidylserine binding | IEA | molecular_function |
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006910 | Phagocytosis, recognition | IEA | biological_process |
| GO:0006911 | Phagocytosis, engulfment | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007338 | Single fertilization | IEA | biological_process |
| GO:0008429 | Phosphatidylethanolamine binding | IEA | molecular_function |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0019897 | Extrinsic component of plasma membrane | IEA | cellular_component |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:2000427 | Positive regulation of apoptotic cell clearance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0309070552 | 0.0480153452 | 0.4069557779 | 0.4100622648 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9652854750 |
| GSE13712_SHEAR | Down | -0.4995508009 |
| GSE13712_STATIC | Down | -0.6532249585 |
| GSE19018 | Up | 0.3266418140 |
| GSE19899_A1 | Down | -0.7360547282 |
| GSE19899_A2 | Up | 0.3715417295 |
| PubMed_21979375_A1 | Up | 0.8266177665 |
| PubMed_21979375_A2 | Down | -0.9915428517 |
| GSE35957 | Up | 0.8926065392 |
| GSE36640 | Up | 1.6309760195 |
| GSE54402 | Down | -0.2380543936 |
| GSE9593 | Up | 0.6875648012 |
| GSE43922 | Down | -0.3336567218 |
| GSE24585 | Up | 0.4179076441 |
| GSE37065 | Up | 0.0328593798 |
| GSE28863_A1 | Down | -0.0126110437 |
| GSE28863_A2 | Down | -0.1616417752 |
| GSE28863_A3 | Up | 0.5547802798 |
| GSE28863_A4 | Down | -0.1497017761 |
| GSE48662 | Up | 1.0966374460 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017018 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038170 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16887494 | Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5 |
| 16887494 | Lactadherin, a glycoprotein secreted by macrophages, binds to phosphatidylserine on apoptotic cells and promote their clearance by macrophages |
| 16887494 | METHODS: The authors isolated and labeled lactadherin and annexin A5 with FITC and compared their ability to detect phosphatidylserine expression by flow cytometry |
| 16887494 | Similarly, lactadherin was more sensitive in detecting phosphatidylserine in red cells induced to express phosphatidylserine |
| 16887494 | Also, in HL 60 cells undergoing apoptosis, lactadherin detected phosphatidylserine expression earlier than annexin A5 |
| 16887494 | In patients with disseminated intravascular coagulation, lactadherin detected phosphatidylserine-expressing platelets in most patients, whereas under similar conditions, FITC-annexin A5 could not |
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