HCSGD entry for MET
1. General information
| Official gene symbol | MET |
|---|---|
| Entrez ID | 4233 |
| Gene full name | met proto-oncogene (hepatocyte growth factor receptor) |
| Other gene symbols | AUTS9 HGFR RCCP2 c-Met |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | NAS TAS | molecular_function |
| GO:0005008 | Hepatocyte growth factor-activated receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | NAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009925 | Basal plasma membrane | IDA | cellular_component |
| GO:0010828 | Positive regulation of glucose transport | IEA | biological_process |
| GO:0014812 | Muscle cell migration | IEA | biological_process |
| GO:0014902 | Myotube differentiation | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | NAS TAS | biological_process |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0030534 | Adult behavior | IEA | biological_process |
| GO:0042593 | Glucose homeostasis | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IMP | biological_process |
| GO:0051450 | Myoblast proliferation | IEA | biological_process |
| GO:0060665 | Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | IEA | biological_process |
| GO:1901299 | Negative regulation of hydrogen peroxide-mediated programmed cell death | IMP | biological_process |
| GO:2001028 | Positive regulation of endothelial cell chemotaxis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8549083925 | 0.0030782493 | 0.9999902473 | 0.1114360768 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0628132594 |
| GSE13712_SHEAR | Up | 0.2661738060 |
| GSE13712_STATIC | Up | 0.1261096451 |
| GSE19018 | Up | 0.0639610608 |
| GSE19899_A1 | Down | -0.4987099088 |
| GSE19899_A2 | Down | -0.9902895506 |
| PubMed_21979375_A1 | Down | -1.3544098192 |
| PubMed_21979375_A2 | Down | -0.7528192002 |
| GSE35957 | Down | -0.3804040800 |
| GSE36640 | Up | 0.0632175136 |
| GSE54402 | Down | -0.4662394143 |
| GSE9593 | Up | 0.3463897045 |
| GSE43922 | Down | -0.5406538991 |
| GSE24585 | Down | -1.2421317150 |
| GSE37065 | Up | 0.7745049514 |
| GSE28863_A1 | Down | -0.4010263348 |
| GSE28863_A2 | Up | 0.4961658386 |
| GSE28863_A3 | Down | -1.3685510969 |
| GSE28863_A4 | Down | -0.1081647620 |
| GSE48662 | Down | -0.2626333877 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| K-252a | DB02152 | EXPT01983 |
| XL184 | DB05153 | - |
| MP470 | DB05216 | - |
| 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide | DB06896 | - |
| N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide | DB06995 | - |
| 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide | DB06997 | - |
| N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide | DB07369 | - |
| 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | DB07969 | - |
| 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | DB08584 | - |
| 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine | DB08700 | - |
| 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE | DB08791 | - |
| Crizotinib | DB08865 | - |
| Cabozantinib | DB08875 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-206 | MIMAT0000462 | MIRT000185 | Western blot | Functional MTI | 19620785 |
| hsa-miR-206 | MIMAT0000462 | MIRT000185 | Luciferase reporter assay//Western blot | Functional MTI | 19710019 |
| hsa-miR-206 | MIMAT0000462 | MIRT000185 | qRT-PCR//ChIP//Luciferase reporter assay//Western blot//Northern blot | Functional MTI | 20388878 |
| hsa-miR-449a | MIMAT0001541 | MIRT006346 | Luciferase reporter assay//Western blot | Functional MTI | 21418558 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000757 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000757 | Luciferase reporter assay | Functional MTI | 20198305 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000757 | Microarray//Western blot//RTPCR | Functional MTI | 20924086 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000757 | Luciferase reporter assay | Functional MTI | 22419847 |
| hsa-miR-34b-5p | MIMAT0000685 | MIRT000758 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | Luciferase reporter assay | Functional MTI | 18834857 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | qRT-PCR//Western blot | Functional MTI | 19006648 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | Luciferase reporter assay//Western blot//Northern blot | Functional MTI | 19029026 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | qRT-PCR//Western blot | Functional MTI | 20309880 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19773441 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22457788 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | Luciferase reporter assay | Functional MTI | 22159222 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000759 | qRT-PCR | Functional MTI (Weak) | 21240262 |
| hsa-miR-1 | MIMAT0000416 | MIRT001357 | Luciferase reporter assay//Western blot | Functional MTI | 19710019 |
| hsa-miR-1 | MIMAT0000416 | MIRT001357 | Luciferase reporter assay//Western blot | Functional MTI | 18818206 |
| hsa-miR-1 | MIMAT0000416 | MIRT001357 | Luciferase reporter assay//Western blot | Functional MTI | 18593903 |
| hsa-miR-1 | MIMAT0000416 | MIRT001357 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001357 | qRT-PCR | Functional MTI (Weak) | 21169019 |
| hsa-miR-1 | MIMAT0000416 | MIRT001357 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-199a-3p | MIMAT0000232 | MIRT001969 | Luciferase reporter assay | Functional MTI | 18456660 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT004292 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR | Functional MTI | 19490101 |
| hsa-miR-34b-3p | MIMAT0004676 | MIRT004825 | Microarray//Western blot//RTPCR | Functional MTI | 20924086 |
| hsa-miR-34b-3p | MIMAT0004676 | MIRT004825 | Luciferase reporter assay | Functional MTI | 22419847 |
| hsa-miR-562 | MIMAT0003226 | MIRT005024 | Luciferase reporter assay | Non-Functional MTI | 19789318 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005167 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT005458 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21225860 |
| hsa-miR-449b-5p | MIMAT0003327 | MIRT006351 | Luciferase reporter assay//Western blot | Functional MTI | 21418558 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT007137 | qRT-PCR | Functional MTI (Weak) | 23418453 |
| hsa-miR-133b | MIMAT0000770 | MIRT016691 | Reporter assay | Functional MTI | 20505319 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT035528 | Luciferase reporter assay | Functional MTI | 23552883 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT035528 | Luciferase reporter assay | Functional MTI | 23553486 |
| hsa-miR-1303 | MIMAT0005891 | MIRT035879 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044529 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24658599 | These results are consistent with the expression of SENP1, microRNA-20a-5p, HGF and phosphorylation of HGF receptor found in human and mouse colon cancers colonised by pks+ E |
| 18938767 | METHODS: I-type insulin-like growth factor receptor (IGF1R), hepatocyte growth factor receptor (HGFR), telomerase reverse transcriptase (TERT) and telomerase associated protein (TP-1) expression were evaluated immunohistochemically on biopsy specimens from 11 mild, 11 moderate and 12 severe active inflammation of UC cases and from 10 normal colonic tissue cases |
| 18938767 | 46%; HGFR: 35 |
| 18938767 | In severe inflammation, all parameters showed decreased epithelial expression; IGF1R showed decreased mRNA expression, while HGFR was overexpressed and TERT showed a decreased tendency |
| 18938767 | CONCLUSIONS: The epithelial expression of IGF1R, HGFR and TERT/TP-1 is elevated in mildly active UC |
| 17066600 | MATERIALS AND METHODS: I-type insulin-like growth factor receptor (IGF1R), hepatocyte derived growth factor receptor (HGFR), telomerase reverse transcriptase (TERT) and telomerase associated protein (TP-1) expression were evaluated immunohistochemically on formalin fixed paraffin embedded biopsy specimen from 10 mild, 10 moderate, and 10 severe active inflammation of ulcerative colitis and from 10 normal colonic tissue |
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