HCSGD entry for MEN1

1. General information

Official gene symbolMEN1
Entrez ID4221
Gene full namemultiple endocrine neoplasia I
Other gene symbolsMEAI SCG2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0000165MAPK cascadeIDAbiological_process
GO:0000400Four-way junction DNA bindingIDAmolecular_function
GO:0000403Y-form DNA bindingIDAmolecular_function
GO:0000785ChromatinIDAcellular_component
GO:0001776Leukocyte homeostasisIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIDAbiological_process
GO:0002051Osteoblast fate commitmentIEAbiological_process
GO:0002076Osteoblast developmentIEA IGIbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006281DNA repairNASbiological_process
GO:0006338Chromatin remodelingIEAbiological_process
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDA IEAbiological_process
GO:0009411Response to UVIDAbiological_process
GO:0010332Response to gamma radiationIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016363Nuclear matrixIDAcellular_component
GO:0016571Histone methylationIEAbiological_process
GO:0018022Peptidyl-lysine methylationIDAbiological_process
GO:0018024Histone-lysine N-methyltransferase activityIDAmolecular_function
GO:0030097HemopoiesisIEAbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIMPbiological_process
GO:0030674Protein binding, bridgingIDAmolecular_function
GO:0031062Positive regulation of histone methylationIEAbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0032154Cleavage furrowIDAcellular_component
GO:0032925Regulation of activin receptor signaling pathwayIEAbiological_process
GO:0034968Histone lysine methylationIDAbiological_process
GO:0035097Histone methyltransferase complexIDA IPIcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045668Negative regulation of osteoblast differentiationIEA IGIbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045736Negative regulation of cyclin-dependent protein serine/threonine kinase activityIMPbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA TASbiological_process
GO:0046329Negative regulation of JNK cascadeIDAbiological_process
GO:0046621Negative regulation of organ growthIEAbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0048704Embryonic skeletal system morphogenesisIEAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051974Negative regulation of telomerase activityIMPbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09716865240.63307300630.65194394601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1394861195
GSE13712_SHEARDown-0.2310623555
GSE13712_STATICDown-0.1788644065
GSE19018Up0.0406393010
GSE19899_A1Up0.0187177036
GSE19899_A2Up0.5922932980
PubMed_21979375_A1Up0.6775726927
PubMed_21979375_A2Up1.6858665495
GSE35957Down-1.1543484886
GSE36640Down-0.0475041972
GSE54402Up0.2410801671
GSE9593Down-0.4570180443
GSE43922Up0.2865717201
GSE24585Down-0.1087804643
GSE37065Down-0.3390168072
GSE28863_A1Up0.1883719597
GSE28863_A2Up0.2600447484
GSE28863_A3Up0.2369145593
GSE28863_A4Up0.1102391632
GSE48662Up0.2395541269

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-18a-3pMIMAT0002891MIRT040940CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049455CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050813CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24694524Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype after antigenic stimulation and dysregulated cytokine production
24694524Menin is required for the expansion and survival of antigen-stimulated CD4 T cells in vivo and acts by targeting Bach2, which is known to regulate immune homeostasis and cytokine production
24694524Menin binds to the Bach2 locus and controls its expression through maintenance of histone acetylation
24694524Menin binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 T cells
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