HCSGD entry for MAP3K5
1. General information
| Official gene symbol | MAP3K5 |
|---|---|
| Entrez ID | 4217 |
| Gene full name | mitogen-activated protein kinase kinase kinase 5 |
| Other gene symbols | ASK1 MAPKKK5 MEKK5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IDA | biological_process |
| GO:0000186 | Activation of MAPKK activity | IDA | biological_process |
| GO:0000187 | Activation of MAPK activity | IEA | biological_process |
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0002931 | Response to ischemia | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0007254 | JNK cascade | IDA | biological_process |
| GO:0007257 | Activation of JUN kinase activity | TAS | biological_process |
| GO:0008631 | Intrinsic apoptotic signaling pathway in response to oxidative stress | IDA IEA | biological_process |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IDA IEA | biological_process |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0045087 | Innate immune response | IEA | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IDA | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4619031154 | 0.0429012955 | 0.9999902473 | 0.3897842596 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1520872820 |
| GSE13712_SHEAR | Down | -0.7288524177 |
| GSE13712_STATIC | Down | -0.0711809871 |
| GSE19018 | Down | -0.1195847611 |
| GSE19899_A1 | Down | -0.5165402749 |
| GSE19899_A2 | Down | -0.0938998667 |
| PubMed_21979375_A1 | Down | -0.2405370212 |
| PubMed_21979375_A2 | Down | -0.6600963859 |
| GSE35957 | Down | -0.2450723491 |
| GSE36640 | Down | -0.0561512466 |
| GSE54402 | Up | 0.1155078190 |
| GSE9593 | Down | -0.1621537786 |
| GSE43922 | Down | -0.5087184401 |
| GSE24585 | Up | 0.8198949120 |
| GSE37065 | Up | 0.3279800329 |
| GSE28863_A1 | Up | 0.0540742161 |
| GSE28863_A2 | Up | 0.7723575951 |
| GSE28863_A3 | Down | -0.8363461434 |
| GSE28863_A4 | Down | -0.0514136255 |
| GSE48662 | Down | -0.1318213631 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-769-3p | MIMAT0003887 | MIRT039091 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24386195 | Western blot analyses were used to determine the changes in mass and post-translational modification of apoptosis signal-regulating kinase (ASK1), phospho-p38 (P-p38 MAPK), and p19(arf) |
| 24386195 | Activation of ASK1, P-p38 MAPK and p19(Arf) correlated with percentage of SAbeta-gal expressing cells after wsCSE treatment |
| 16731828 | Here, we show that high glucose induces activation of apoptosis signal-regulating kinase 1 (ASK1), an apoptosis-inducing signal that mediates endothelial cell senescence induced by hyperglycemia |
| 16731828 | High glucose induced a time-dependent increase in the levels of ASK1 expression and its activity in human umbilical vein endothelial cells (HUVECs) |
| 16731828 | However, transfection with an adenoviral construct including a dominant negative form of ASK1 gene significantly inhibited SA-beta-gal activity induced by high glucose |
| 16731828 | In addition, infection with an adenoviral construct expressing the constitutively active ASK1 gene directly induced an increase in the levels of SA-beta-gal activity |
| 16731828 | Activation of the ASK1 signal also enhanced plasminogen activator inhibitor-1 (PAI-1) expression in HUVECs |
| 16731828 | Our results suggest that hyperglycemia accelerates endothelial cell senescence and upregulation of PAI-1 expression through activation of the ASK1 signal |
| 16731828 | Thus, ASK1 may be a new therapeutic target to prevent vascular ageing and thrombosis in diabetic patients |
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