HCSGD entry for MAP3K3
1. General information
| Official gene symbol | MAP3K3 |
|---|---|
| Entrez ID | 4215 |
| Gene full name | mitogen-activated protein kinase kinase kinase 3 |
| Other gene symbols | MAPKKK3 MEKK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0004672 | Protein kinase activity | IDA IEA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IEP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0537391171 | 0.9703399833 | 0.5053903640 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0522254904 |
| GSE13712_SHEAR | Up | 0.3435143786 |
| GSE13712_STATIC | Up | 0.0545820219 |
| GSE19018 | Up | 0.2724588548 |
| GSE19899_A1 | Down | -0.1200001529 |
| GSE19899_A2 | Up | 0.2894712351 |
| PubMed_21979375_A1 | Up | 0.2390648828 |
| PubMed_21979375_A2 | Up | 0.5155395120 |
| GSE35957 | Up | 0.0463313511 |
| GSE36640 | Down | -0.0120911938 |
| GSE54402 | Down | -0.1102206906 |
| GSE9593 | Up | 0.0969275953 |
| GSE43922 | Up | 0.0460127879 |
| GSE24585 | Up | 0.4146952346 |
| GSE37065 | Down | -0.1255553854 |
| GSE28863_A1 | Up | 0.8023531391 |
| GSE28863_A2 | Up | 0.5652847905 |
| GSE28863_A3 | Up | 0.1667810632 |
| GSE28863_A4 | Up | 0.0388884391 |
| GSE48662 | Up | 0.1559391927 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021476 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021851 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023113 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041562 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26029164 | Furthermore, we investigated the correlated expression patterns of Cdc14B, ESCO1, KPNA5, MAP3K3, and CSIG during cell cycle and senescence progression, which imply the important pathways CSIG regulating cell cycle and senescence |
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