HCSGD entry for MDM4
1. General information
| Official gene symbol | MDM4 |
|---|---|
| Entrez ID | 4194 |
| Gene full name | Mdm4 p53 binding protein homolog (mouse) |
| Other gene symbols | HDMX MDMX MRP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA NAS | cellular_component |
| GO:0006461 | Protein complex assembly | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA TAS | molecular_function |
| GO:0008283 | Cell proliferation | IEP | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | IEP | biological_process |
| GO:0042177 | Negative regulation of protein catabolic process | IMP | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0045023 | G0 to G1 transition | IEP | biological_process |
| GO:0050821 | Protein stabilization | IEP | biological_process |
| GO:0071157 | Negative regulation of cell cycle arrest | IEA | biological_process |
| GO:0071456 | Cellular response to hypoxia | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9190929790 | 0.0217999012 | 0.9999902473 | 0.2847618859 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2850091710 |
| GSE13712_SHEAR | Up | 0.4305412081 |
| GSE13712_STATIC | Up | 0.0293698145 |
| GSE19018 | Down | -0.1774611674 |
| GSE19899_A1 | Down | -0.2282185738 |
| GSE19899_A2 | Down | -0.8726681424 |
| PubMed_21979375_A1 | Down | -0.8946590602 |
| PubMed_21979375_A2 | Down | -0.8508803883 |
| GSE35957 | Down | -0.0673236660 |
| GSE36640 | Down | -0.9963204025 |
| GSE54402 | Down | -0.0199847901 |
| GSE9593 | Down | -0.3140454294 |
| GSE43922 | Down | -0.8408953154 |
| GSE24585 | Up | 0.2009219025 |
| GSE37065 | Down | -0.1788394886 |
| GSE28863_A1 | Up | 0.5965823102 |
| GSE28863_A2 | Up | 0.3666808119 |
| GSE28863_A3 | Down | -0.2480604562 |
| GSE28863_A4 | Down | -0.2357118814 |
| GSE48662 | Up | 0.0624030564 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-191-5p | MIMAT0000440 | MIRT006570 | Luciferase reporter assay | Functional MTI | 21084273 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT004403 | Microarray | Functional MTI (Weak) | 19461653 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021357 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024671 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026375 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030817 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052186 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27160904 | We find that a reduced USP1 level causes aberrant aggregation of its target FANCD2 concomitant with replication stress, accumulation, and colocalization of gamma-H2Ax and p53-binding protein 1 (53BP1) in large and unusual sparse DNA damage foci and an increased number of polyploid cells and cells arrested in G2/M, as well as a sensitization of senescence-bypassing cells to DNA interstrand crosslinking-mediated cell death |
| 26181202 | Targeting Mdmx to treat breast cancers with wild-type p53 |
| 26181202 | This is primarily achieved through elevation in the expression of the key inhibitors of p53: Mdm2 or Mdmx (also called Mdm4) (reviewed) |
| 26181202 | Here we show that Mdmx is unexpectedly highly expressed in normal breast epithelial cells and its expression is further elevated in most luminal BrCas, whereas p53 expression is generally low, consistent with wt p53 status |
| 26181202 | Inducible knockdown (KD) of Mdmx in luminal BrCa MCF-7 cells impedes the growth of these cells in culture, in a p53-dependent manner |
| 26181202 | Importantly, KD of Mdmx in orthotopic xenograft transplants resulted in growth inhibition associated with prolonged survival, both in a preventative model and also in a treatment model |
| 26181202 | Growth impediment in response to Mdmx KD was associated with cellular senescence |
| 26181202 | The growth inhibitory capacity of Mdmx KD was recapitulated in an additional luminal BrCa cell line MPE600, which expresses wt p53 |
| 26181202 | Further, the growth inhibitory capacity of Mdmx KD was also demonstrated in the wt p53 basal-like cell line SKBR7 line |
| 26181202 | These results identify Mdmx growth dependency in wt p53 expressing BrCas, across a range of subtypes |
| 26181202 | Based on our findings, we propose that Mdmx targeting is an attractive strategy for treating BrCas harboring wt p53 |
| 23262034 | Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy |
| 23262034 | In addition, tumor cells dampen p53 activities via overexpression of p53-negative regulators, in particular 2 structurally related proteins, Mdm2 and Mdm4 |
| 23262034 | And yet, Mdm2 and Mdm4 possess p53-independent activities, which also contribute to tumor formation and progression |
| 23262034 | Given that Mdm2 and Mdm4 inhibit p53 activities to promote tumor development, small molecules and peptides were developed to abrogate the inhibition of p53 by Mdm proteins |
| 21641119 | P53-binding protein 1: a new player for tumorigenesis and a new target for breast cancer treatment |
| 21641119 | Recently, accumulating evidences have showed that p53-binding protein 1 (53BP1) plays an important role in DNA double-strand breaks (DSBs) repair induced by radiation |
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