HCSGD entry for MCM5
1. General information
| Official gene symbol | MCM5 |
|---|---|
| Entrez ID | 4174 |
| Gene full name | minichromosome maintenance complex component 5 |
| Other gene symbols | CDC46 P1-CDC46 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003678 | DNA helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006260 | DNA replication | IEA TAS | biological_process |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0042555 | MCM complex | IDA IEA | cellular_component |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9642804681 | 0.0002044983 | 0.9999902473 | 0.0251523364 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5672139585 |
| GSE13712_SHEAR | Down | -0.3064332782 |
| GSE13712_STATIC | Down | -0.4655880886 |
| GSE19018 | Down | -0.0335719075 |
| GSE19899_A1 | Down | -1.7343028433 |
| GSE19899_A2 | Down | -2.9740773968 |
| PubMed_21979375_A1 | Down | -0.6250304158 |
| PubMed_21979375_A2 | Down | -2.9042110469 |
| GSE35957 | Down | -2.4889786865 |
| GSE36640 | Down | -2.1933823836 |
| GSE54402 | Down | -0.4100465103 |
| GSE9593 | Down | -1.9136088239 |
| GSE43922 | Down | -1.3236148084 |
| GSE24585 | Up | 0.3161893148 |
| GSE37065 | Down | -0.6772615545 |
| GSE28863_A1 | Down | -0.0575243313 |
| GSE28863_A2 | Up | 0.6853502813 |
| GSE28863_A3 | Down | -0.2481318580 |
| GSE28863_A4 | Up | 0.0980049705 |
| GSE48662 | Down | -1.0767604081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-885-5p | MIMAT0004947 | MIRT005462 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 21233845 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016518 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016518 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-1 | MIMAT0000416 | MIRT023962 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025521 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-484 | MIMAT0002174 | MIRT041977 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048840 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050677 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12958145 | Replication of primitive cells and myocytes was assessed by MCM5 labeling, myocyte mitotic index, and telomerase function |
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