HCSGD entry for MCM4
1. General information
| Official gene symbol | MCM4 |
|---|---|
| Entrez ID | 4173 |
| Gene full name | minichromosome maintenance complex component 4 |
| Other gene symbols | CDC21 CDC54 NKCD NKGCD P1-CDC21 hCdc21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003678 | DNA helicase activity | IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | IEA NAS TAS | biological_process |
| GO:0006268 | DNA unwinding involved in DNA replication | IEA | biological_process |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0042555 | MCM complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8796210668 | 0.0032191482 | 0.9999902473 | 0.1142324361 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1642482969 |
| GSE13712_SHEAR | Up | 0.1705117995 |
| GSE13712_STATIC | Up | 0.3037974847 |
| GSE19018 | Down | -0.1510020665 |
| GSE19899_A1 | Down | -0.9655118367 |
| GSE19899_A2 | Down | -1.7063333809 |
| PubMed_21979375_A1 | Down | -0.5582485801 |
| PubMed_21979375_A2 | Down | -2.1666159707 |
| GSE35957 | Down | -1.1656611881 |
| GSE36640 | Down | -2.1673749331 |
| GSE54402 | Up | 0.0076791041 |
| GSE9593 | Down | -0.7942855327 |
| GSE43922 | Down | -0.8250334636 |
| GSE24585 | Up | 0.1853477021 |
| GSE37065 | Down | -0.1355700910 |
| GSE28863_A1 | Up | 0.0055978853 |
| GSE28863_A2 | Up | 1.2288349985 |
| GSE28863_A3 | Down | -0.2763431399 |
| GSE28863_A4 | Down | -0.0979325443 |
| GSE48662 | Down | -0.8036670160 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016612 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016612 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-1 | MIMAT0000416 | MIRT023946 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025322 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030629 | qRT-PCR;Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-501-3p | MIMAT0004774 | MIRT037991 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT038934 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042917 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044489 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047147 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052176 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
